The Sherman Lab aims to understand the transcriptional and epigenetic gene-regulatory networks that underlie tumor-stroma interactions in pancreatic cancer, and to target these networks for therapeutic benefit. Our research focuses on the mechanisms by which stromal fibroblasts in the pancreatic tumor microenvironment influence cancer cell gene expression, metabolism, and growth. Our laboratory uses a multidisciplinary approach to investigate the mechanistic underpinnings of the pancreatic tumor microenvironment, including mouse models of pancreatic cancer, three-dimensional cell culture systems such as patient-derived organoids, and diverse molecular- and cell-biological techniques focused on gene regulation.
We are seeking a highly motivated Postdoctoral Scholar to conduct research in areas of tumor immunology and tumor microenvironment, identifying cells and their mediators as critical regulators of cancer development. Specific projects will be determined by the applicants skill set and articulated research interests.
The ideal candidate for this position will be highly interactive, but capable of working independently on research focused on tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function, and how these stromal mechanisms affect cell fate and function in the pancreatic epithelium.
The Postdoctoral Scholar will be the primary strategist in scientific aspects of the assigned project, and in that regard may participate in supervision of some activities of research assistants, frequently taking responsibility for expensive equipment and experiment design. It is expected that the Postdoctoral Scholar will write scientific papers, abstracts, and submit manuscripts for publication and seek out and apply for grants and additional funding to support this research.
Salary for this position aligns with the NIH Scale .
PhD in related field of research
Experience with model organisms, cell culture, functional analyses (proliferation/apoptosis assays, Western blot, real-time qPCR, etc.), and molecular cloning
First authorship on at least one paper in a peer-reviewed English language journal
Excellent written and verbal communication skills
Willingness to compete for internal and external funding
No more than 1 year of postdoctoral experience
Experience in mouse models of cancer and high-throughput sequencing
Candidates should upload a cover letter describing your relevant qualifications / one-page research description with relevant publications, future interests, and expected start date; CV; and names and contact information for three references.
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