Dr. Min-Hao Kuo, Department of Biochemistry and Molecular Biology, Michigan State University, seeks a research associate to work on his project that focuses on Alzheimer's disease drug discovery using aggregation of hyperphosphorylated tau as the target. The overall research involves hyperphosphorylated tau protein preparation, in vitro drug screen and verification, using both biochemical and cell-based means. Required expertise include recombinant protein expression and purification, high-throughput screen assay establishment and execution, as well as subsequent secondary and orthogonal assays for verification. In addition, ability to perform mammalian tissue culture and cellular viability tests are expected. Excellent English writing and communication skills are required.
Description of duties:
Independent planning, execution, and interpretation of experiments; regular communication with the PI; collaborating with other members in the lab on this project; mentoring graduate and undergraduate trainees; writing manuscripts for research products.
Equal Employment Opportunity Statement
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.
Doctorate- Biochemistry or related
PhD with extensive experiences in (1) quantitative examination of protein amyloidogenesis and fibrillogenesis, (2) recombinant protein expression and purification, (3) molecular cloning, (4) kinetic and statistical analysis of protein folding, and (5) high-throughput screening for drug discovery.
Excellent communication (oral and writing) skills in English.
Required Application Materials
Curriculum vitae, cover letter, and names and contact information for three references.
Review of applications will begin on October 14, 2020 and will continue until the position has been filled.
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