Conduct research on the developmental reprogramming of gestational exposure to excess testosterone and the transfer of programmed defects to the next generation. Research will involve generation of new cohort of experimental animals, animal experimentation, tissue collection and laboratory investigations to determine the effects of prenatal testosterone excess on epigenetic, molecular, and functional alterations in reproductive and cardio-metabolic systems. Another aspect that will be studied is whether overfeeding will amplify the adverse effects of prenatal testosterone treatment on the reproductive and metabolic systems. The research findings completed by the candidate will contribute towards meeting funding objectives for the RO1 grant “Multigenerational Effects of Gestational Testosterone Excess.” and contribute towards University’s research success. Specific duties will involve the following:
Investigate the molecular mechanisms by which exposure to excess testosterone during pregnancy affect reproductive and metabolic function. Establish scientific evidence on the hypothesis of how inappropriate exposure to excess testosterone such as that seen in PCOS and hyperandrogenic disorders reprogram the trajectory of the developing individual using a combination of large animal, cellular and molecular approaches
Carry out bench research responsibilities including data collection, analysis (graphing and statistics), quality control, and involvement in manuscript/grant preparation
Maintain detailed and organized research notes, write research manuscripts and grant proposals
A Ph.D. in biological sciences (or related field) and a strong background in immunohistochemical and molecular techniques as well as image analyses. This individual is expected to demonstrate the capacity for critical scientific thinking and creativity, design and conduct studies, perform data analysis, assist with training, and prepare manuscripts for publication. Excellent communication skills (writing and speaking). The successful candidate will enjoy a collaborative atmosphere both within the University of Michigan and an extensive collaborative network. The applicant will be expected to work as part of a multi-disciplinary, highly collaborative research team that interacts with other laboratories across the University of Michigan.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 189241
About University of Michigan - Ann Arbor
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.