We are accepting applications for a postdoctoral fellow interested in the study of cellular signaling and the regulation of gene expression in the protozoan parasite Toxoplasma gondii. Toxoplasma is an opportunistic pathogen that causes severe disease in congenitally infected infants and immune compromised patients. Toxoplasma is a significant clinical challenge because the parasite converts into a latent tissue cyst form that evades immunity and current drugs. The tissue cysts are central to pathogenesis, transmission, and behavioral changes in the host.
Our laboratory seeks to solve this clinical problem by obtaining a better understanding of the mechanisms driving tissue cyst formation. We use state-of-the-art multi-disciplinary approaches to interrogate how the parasite alters translation and reprograms its genome to convert to the latent stage of infection.
The successful applicant will contribute to exciting projects examining the myriad ways gene expression is regulated in the context of cyst formation. This includes study of multiple mechanisms including transcription, epigenetics, epitranscriptomics, and translational control. Our long-term goal is to identify novel points of therapeutic intervention that will thwart the development and maintenance of Toxoplasma tissue cysts.
This is a NIH position in the laboratory of Bill Sullivan https://wjsulliv.wixsite.com/sullivanlab
Our laboratory is a part of the
Internal Number: 9852
About Indiana University
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.