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The Brent lab is seeking a senior postdoctoral fellow to support our research in the causes and consequences of non-genetic phenotypic variation.
The project specifically includes design and construction of "controllers", complex artificial systems allowing tunable variation-suppressed suppressed expression of genes in mammalian cells. The fellow may also be involved in efforts to develop Augmented Reality (AR) methods and protocols to aid the controller project, and to in work to learn how to use AR to enable other researchers to better carry out a variety of fundamental experimental manipulations.
This position will support research activities that include but are not limited to:
Generation of variation-suppressed expression constructs to control genes in mammalian cells.
Generation and testing of large numbers of intermediate constructs carrying out subfunctions, en route to assembly and testing of the best expression controllers.
Facile of contemporary DNA assembly methods including in vitro assembly and relevant construction methodologies in Saccharomyces cerevisiae
Use of software to plan DNA constructions and ability to quickly use lab and other image cytometric software to quantify gene expression in single mammalian cells.
Use of flow cytometry and flow cytometric method
Updating of standard molecular cell biology/genetic techniques, including retroviral and lentiviral gene transduction, CRISPR, and next gen sequencing analysis, as methods change, based on input from other scientists, literature
Engagement with rapidly developing AR and ancillary technologies to aid research projects, willingness to participate in developmental work that will enable others to benefit from this new medium, and possible help with translation to AR representations.
Aid conventional training, supervision and evaluation of laboratory staff and students.
Development and updating of laboratory procedures, drafts of reports and manuscripts and the presentation of data at lab meetings develop and establish published
Participation in local and national scientific meetings.
Collaboration with PI for the submission of research grants and the submission of progress reports to identify funding and manage projects and research studies.
For this position, we are hoping to find an extraordinary and dedicated individual. The lab is a multidisciplinary environment and offers a number of intellectual growth paths by which scientists willing to engage can continue to develop scientifically.Initial funding for this position is for one year but position would be maintained if funding permits.
PhD. and 5+ years experience in Biochemistry, Genetics, Cell Biology or related areas; and a strong background in molecular biology, and DNA work, demonstrated facility with contemporary DNA assembly methods.
Desired: Experience with rigorous genetics in a prokaryotic system, or in the model systems S. cerevisiae, C. elegans, or D. melanogaster. 10 or more years of relevant research experience with some combination of model organism genetics, molecular biology, single cell assays, DNA/genomic based analytical methods, and cell culture.
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.