Research - Laboratory/Non-Laboratory, Staff/Administrative
Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Gastroenterology. The position is for the Medical School Campus.
The Division of Gastroenterology at the Washington University School of Medicine represents one of the finest examples of an academic training program, dedicated to the study of digestive and liver diseases. The balance of outstanding faculty, exemplary facilities, and a cohesive philosophy ensure consistent excellence across the missions of maintaining national prominence in research, teaching and patient care. The Division leads an NIDDK funded Digestive Diseases Research Cores Center to facilitate basic and translational research.
We are a basic-translational lab researching mechanisms and pathways of intestinal disease. Ultimately, our goal is to leverage this understanding to identify novel therapeutic approaches which will address the unmet needs of patients affected by Crohn’s disease, ulcerative colitis, mucositis and colon cancer. Investigational tools include modern molecular biology, genetic engineering, microbiome studies, animal models (mice), human tissues, and organoids (mouse and human derived). A major focus of our studies is directed at understanding how tryptophan metabolism along the kynurenine (Try-Kat) pathway shapes intestinal inflammation, as well as the development of colon cancer. The Try-Kat pathway is an immunotherapy target and interacts with neoplastic pathways in the colon epithelium. The current position will work to advance studies which will define how manipulation of the Try-Kat pathway can be leveraged to improve therapy of colon cancer and reduced off target effects of DNA damaging therapies (e.g. radiation enteritis and chemotherapy mucositis).
This position is full-time with approximately 40 hours per week. Hours are generally normal business hours but may vary due to the timing for experiments and other research activity deadlines.
Doctorate degree (M.D., Ph.D., or equivalent).
Experience with techniques in molecular biology, cell biology, biochemistry and vertebrate animal models.
Good oral and written communication skills.
Ability to perform the work described and wear protective equipment when necessary.
Base pay commensurate with experience.
Experience studying animal models (GEMMs), cancer biology, radiation biology, immunotherapy, genetics, cell culture models and organoid/ex vivo culture.
Familiar or proficient with experimental approaches described above.
Ability to carry out cell culture experiments, and handle, monitor, and breed mice, with competency performing small animal procedures, tissue processing, immunostaining, and microscopy.
Ability to work independently and have troubleshooting skills, with critical, analytical, and creative thinking.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.