The Department of Molecular Biology and Biochemistry in the School of Biological Sciences is accepting applications in the areas of adaptive or innate immunology and neuroinflammation in relationship to Alzheimer's disease. The person in the position will perform experiments with human brain samples cultured neurons and transgenic mice under the direction of Dr. Charles Glabe. This NIH-funded project examines natural antibodies (NA) and autoantibodies (AA) that are correlated with the incidence or avoidance of Alzheimer's disease and the pathological significance of the immune response to amyloid. The overarching hypothesis is that the immune response to amyloid is similar to the immune response to microbial pathogens, where NA are produced by a T cell independent immune response and forms first response to the formation of amyloids. We hypothesize that NA and AA are associated with protection against AD and may serve as biomarkers of AD. This person also will work on the role of inflammatory cell death pathways in the pathogenesis of AD. Renewal of the appointment will be contingent on performance and the availability of adequate funding.
The University of California, Irvine is ranked among the nation's best research institutes with over $90,000,000 in current funding. Enrichment opportunities abound through the Alzheimer's Disease Research Center, the Memory Impairment and Neurodegenerative Disease Institute and the Center for the Neurobiology of Learning and Memory. Irvine has a pleasant climate, five miles from the beach.
Requirements Ph.D. in immunology, neuroscience or cell biology and an interest in Alzheimer's disease. Experience with monoclonal antibodies, inflammation and experience working with transgenic mice preferred. Experience with informatics is also desired.
Candidate performs research, provides university and/or public service, demonstrates professional competency and activity of high quality and significance.
Qualified candidates should submit their curriculum vitae, a cover letter, and the names and contact information of three references to the following on-line recruitment URL:
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.