Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Department Name/Job Location:
This position is in the Department of Pediatrics, Division of Infectious Diseases. This position is for the Medical School Campus.
The Janowski lab discovers and characterizes novel viruses, with a current focus on astrovirus VA1 (VA1). Astroviruses have been long assumed to be pathogens restricted to the gastrointestinal tract, but multiple human patients have been identified to have invasive astrovirus infection of the central nervous system. We have successfully cultured VA1, the most commonly identified astrovirus species from cases of human encephalitis and developed the first cell culture model that supports replication of VA1 in central nervous system cells. In parallel, we have also developed a murine in vivo model of infection, and surprisingly, VA1 causes myocarditis in mice, suggesting this virus could have additional tissue tropisms beyond the gastrointestinal tract and central nervous system. We are now characterizing the pathogenesis of infection through our cell culture and mouse models of infection. These approaches will allow for important insights into the biology of an emerging family of viruses that cause invasive diseases in humans.
In addition, we are interested in characterizing conserved viral elements between viral families. VA1 contains a highly conserved RNA sequence known as the stem-loop II-like motif (s2m) that is also present in SARS coronaviruses including SARS CoV-2. Currently, the function of this motif is completely unknown despite its presence in multiple viral families. We have developed a reverse genetics system for VA1 and are using it to dissect the function of this motif.
We are seeking an energetic, highly-motivated postdoctoral research associate to carry out in vitro and in vivo experiments. Techniques include RNA extraction, PCR, cloning and molecular biology, biochemistry, cell/tissue culture, fluorescence and confocal microscopy, and analysis of RNAseq or other data sets.
Ph.D., M.D., or equivalent terminal doctoral degree.
Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Applicants should send a cover letter including a description of career goals, curriculum vitae, recent publication(s), and the names and contact information for 3 references (including the Ph.D. mentor, if applicable) to Dr. Andrew Janowski (firstname.lastname@example.org).
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Experience with common molecular biology techniques, cell culture, virology, PCR, cloning, microscopy, mouse models of infection, and flow cytometry would be beneficial.
Experience in immunology, virology, and molecular biology.
Strong research skills.
Effective oral and written communication skills.
Highly motivated and creative.
Ability to work both independently and within a team.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.