Research - Laboratory/Non-Laboratory, Staff/Administrative
Department: MED-Urology Salary/Grade: RES/
Post-doctoral position is available immediately at Northwestern University in the Feinberg School of Medicine, Department of Urology. We are seeking enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. Prospective candidates will have the opportunity to submit publications, as well as gain access to human trial specimens that will contribute to the next generation of therapies. In addition, Northwestern University offers an extremely stimulating and nourishing academic environment, with rich resources to facilitate career development for young scientists.
What we offer: Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities with the possibility to work on cutting edge and novel translational research projects. We use a wide spectrum of methods: biochemistry, cloning, cell culture, qRT-PCR, FACS, ELISA, cell-based assays (proliferation), apoptosis, migration, 3D invasion, organoid culture, shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, next generation sequencing, chromatin immunoprecipitation, single-cell RNA-seq, bioinformatic analysis, animal models and in vivo tumor models as well as tumor biopsies. We have won a number of external research grants and are involved in several national and international collaborative projects. Significant time is spent developing critical research skills and scientific writing and editing. Potential for training grant and independent funding depending on qualifications.
The selected candidate will work on the genetic, epigenetic, and immune mechanisms of cancer biology and epigenetic-based therapies in urologic cancers. This fellowship will use bladder cancer as a model system for solid-tumor biology to better investigate tumor development, epigenetic modifications and immune response to cancer. No prior experience with bladder cancer is required, but candidates should have an interest in molecular biology, solid tumor cancer and epigenetics.
The main focus of the lab is related to: 1) how does histone modification affect tumor aggressiveness and can this be used as a therapy? 2) How do epigenetics affect immune response?Our overall goal is to improve outcomes for patients with urologic cancers by focusing on the development and translational application of novel therapeutics.
Research projects associated with this fellowship include:
Mechanisms of T-cell biology and immune activation in genitourinary disorders (including cancer)
Mechanisms resistance to therapy
Mechanisms of T cell tolerance
Epigenetic regulation of T cell activity
Novel checkpoint and immune regulatory therapies. Our laboratory consists of a diverse group of clinicians and scientists interested in investigation of immune biology in disease.
PhD or MD/PhD
Strong track record and research background in molecular and cell biology
Desire for independent research
Experience in bioinformatics (R, python) and animal models
Experience in cancer research
Expertise in one or more of the following areas: epigenetics, immunology, functional genomics or other high-throughput screening methods, in vivo tumor models, advanced microscopy methods, and biochemistry.
Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
Internal Number: 38956
About Northwestern University
Northwestern University is a major private research university with 12 academic divisions located on three campuses in Evanston, Chicago, and Education City in Doha, Qatar. We have approximately 2,500 full-time faculty members, 17,000 graduate and undergraduate students, and over 5,700 full and part-time staff. Northwestern University combines innovative teaching and pioneering research in a highly collaborative environment. It provides students and faculty exceptional opportunities for intellectual, personal and professional growth.