Conduct laboratory research on the synthesis of novel chemical compounds and their evaluation as anti-cancer therapeutic targeting the DNA damage response and DNA repair. Participate as part of a collaborative group employing chemical genetic approaches to elucidate the impact of inhibiting the DNA -protein interactions on critical cellular processes.
Primary Duties and Responsibilities:
- Medicinal chemistry/organic synthesis of small molecule chemical inhibitors. Purification and analytical analysis of newly synthesized compounds.
- Other laboratory techniques including: cell cultures, nucleic acid preparation and analysis, nucleic acid enzymology, protein purification, and assays.
- Assist in the preparation of written reports, abstracts, and manuscripts.
- Clean glassware and instruments. Assist in keeping the laboratory clean, neat, and tidy. Maintain laboratory instruments. Equipment usage and repair records according to SOPs.
- Other duties as assigned not covered by responsibilities above.
Bachelor's degree in chemistry.
Combinations of education and related experience may be considered.
Knowledge of organic chemistry and basic synthetic procedures. Excellent organizational and communication skills, especially related to discussion of data interpretation. Ability to work independently to apply basic knowledge of laboratory methods, materials, techniques, and principles of physical/biological sciences. Familiarity with chemdraw, scifinder, Microsoft Office Suite, including Word, Excel, and PowerPoint.
Master's degree. One year of experience in a scientific research laboratory. Experience in medicinal or synthetic organic chemistry.
Working Conditions / Demands
Equipment utilized: Flash chromatography purification system, LC-MS/MS, NMR spectroscopy, Rotovap, centrifuges, gel apparatus, microscopes, biotage, and other laboratory equipment.
Salary Plan: RS
Salary Grade: 07
Job Function: Research
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Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.