Research - Laboratory/Non-Laboratory, Staff/Administrative
The Preclinical Research Center is seeking an engaged employee committed to performing high-quality testing in a fast-paced setting. This position will be a part of a team working to develop and support innovative therapies for diseases with major public health significance. This research focuses on neurologic, metabolic (e.g. diabetes and obesity), and infectious disease (e.g. COVID19). The employee must be attentive to detail and able to follow precise written protocols. The employee will be primarily responsible for performing enzyme-linked immunosorbent assays (ELISA), radioimmunoassays (RIA) and Luminex multiplexing procedures on animal specimens. Therefore, the candidate must have experience with proper pipetting technique. The employee must be able to handle animal specimens and perform assays while wearing appropriate personal protective equipment (may include a surgical gown, surgical mask, face shield, double gloves).
Planning and performing analytical assay validations/verifications may be required; this would require some basic statistical analysis and composition of written reports. Planning, constructing and aliquoting assay controls (from pools of previously tested animal serum samples) in targeted concentration ranges is required occasionally (2-3 times per year).
Some equipment maintenance and calibration will be required to maintain specific equipment used in assays. Although there is some routine in the daily/weekly work tasks, the employee must be flexible to accommodate unexpected requests for alternate tasks and assay priorities. The position will be responsible for monitoring reagent and supply levels and maintaining appropriate levels to perform routine and unexpected assays. This work requires compliance with UMN safety, chemical waste and radiation procedures (with occasional audits by University groups to ensure compliance with regulations).
Organizational skills for maintaining chain-of-custody information, samples and results are important for this position. The employee may have the opportunity to contribute to study design and coordination. When not occupied with routine tasks, the employee is expected to participate in other lab tasks as assigned to advance the team’s work. A breakdown of duties includes but is not limited to:
Diagnostic Sample Intake and Processing (25%) • Under general supervision, prepare submission forms, documents, data, and tubes/swabs/containers for the resident animals based on planned clinical care. • Facilitate the daily receipt and storage of diagnostic samples, while adhering to strict time constraints and deadlines • Perform accurate handling, sorting, labeling, and processing of diagnostic samples. • Establish the destination and/or procedures to be performed on the samples. • Under general supervision inspect and evaluate incoming diagnostic samples to determine their viability, quality, and appropriateness for further diagnostic work-up. • Demonstrate solid problem solving skills when handling submissions that arrive with incomplete or limited information. • Initiate advanced investigations on inadequate/inaccurate submissions by utilizing a working knowledge of patient history, diagnostic trends, and testing expectations. • Log each diagnostic submission based on the findings of the submission interpretations listed above and the testing requirements as assigned. • Track diagnostic samples, enter test requests and sample data, and extract test results and reports.
Diagnostic Sample Routing (10%) • Organize diagnostic submissions into groups based on their specific test requests and priority level status. • Coordinate the distribution of diagnostic samples to downstream labs in a predetermined order based on the testing requirements and priority. • Compile the corresponding documents and test requests for each group and distribute appropriately. • Demonstrate excellent time management skills by adhering to strict time constraints, to comply with the testing schedules of downstream collaborators, and prioritize sample distribution accordingly. • Inform downstream sections of incoming submissions of high priority, off-schedule testing requests, or changes to in-progress testing.
Diagnostic Sample Processing (40%) • Prepare and perform sample processing for diagnostic testing while adhering to strict BSL2 safety guidelines. • Under general supervision determine the appropriate sample preparations for diagnostic testing based on the assigned test requests and sample types available, on a case by case basis. • Prepare sample aliquots by performing centrifugation, calculating the necessary sample volume, and pipetting material into appropriate testing vessels, as determined by the test requirements. • Calculate serial dilutions and create extraction records for molecular diagnostic testing. • Anticipate the volume of reagents and controls necessary for diagnostic sample testing and independently calculate and prepare stock solutions and kits • Maintain working knowledge on the operation and maintenance of basic laboratory equipment such as scales, lifts, centrifuges, shakers, pipettes, biosafety cabinets, incubators, and -80 freezers. • Routine ELISA, RIA, and chemiluminescence assay performance
Diagnostic Sample Outsourcing (10%) • Coordinate the shipment of biological samples for outsource testing, research collaborations, and case consultations. • Attend bi-annual training and maintain certification in Category A and B Infectious Substance and Dry Ice Shipping. • Assemble diagnostic samples and associated documents for outsourcing; including state, federal, and international permits (e.g. CITES) and customs documents. • Prepare shipments in compliance with state and federal shipping regulations. • Manage shipping software and regulation updates for our preferred courier services.
Miscellaneous Duties (15%) • Perform laboratory maintenance duties as assigned • Data entry as needed • Oversee inventory of laboratory supplies and order fulfillments • Perform light receptionist duties as needed
All required qualifications must be documented on application materials.
Required: • BA/BS or a combination of related education and work experience to equal four years; • Demonstrated ability to apply knowledge and skill to a recurring task or activity with emphasis typically on precision and timeliness of execution.
Preferred: • Bachelor's degree in biology or related field • Two years of relevant scientific/laboratory experience • Experience working under a quality assurance system (or GLP experience)
Internal Number: 336614
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.