The lab is interested in how signals from membrane receptors are transduced to the nucleus altering gene expression, cell shape, proliferation and differentiation. We are particularly interested in tyrosine-specific protein kinases in breast and prostate cancer, as well as lymphoma/leukemia. A second project investigates a novel transmembrane tyrosine kinase, Mer, cloned and sequenced in our lab. We are attempting to define the mechanism by which a tyrosine kinase sends anti-apoptotic signals without stimulating proliferation and how it results in chemoresistance in leukemia and other cancer cells. Experimental goals include characterizing circulating and tumor-infiltrating lymphocyte populations in correlative studies and murine models of cancer immunology, analysis of the genetic diversity of T cell receptor and B cell receptor repertoires, and gene-expression profiling of the tumor microenvironment using next-generation sequencing. The responsibilities of this position include isolation and characterization of tumors and the tumor immune microenvironments. Examples include, serving as the technical and functional expert in a variety of research related techniques, collaborating and consulting effectively with a large, dynamic team of clinical and research colleagues as well as the use of bioinformatics techniques to analyze sequencing data and prepare data reports.
Education and Experience:
Certification in Flow Cytometry and Molecular Diagnostics or Genetics is recommended, as is facility with basic scripting in the Python and R programming languages, though these are not required.Particular expertise with human patient clinical samples preferred.
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