Research - Laboratory/Non-Laboratory, Staff/Administrative
This position will study growth factor receptor targeted therapy for breast and ovarian cancer biology and metastasis. Ongoing research projects in the laboratory include the study of growth factor signaling in regulating metastasis of breast cancer, use of animal models to study the effect of signaling inhibitors and natural killer cell based drugs on biology and metastasis of breast cancer, development of metastasis signatures as biomarkers for selecting patients for targeted therapy using gene expression profiling and proteomics, and in vivo imaging to monitor response to targeted therapies.
Specific responsibilities/duties include:
Research – 60-65%: Performing supervised scientific and professional laboratory work on growth factor receptor signaling and targeting in breast cancer. The work will involve analyzing signaling pathways using cell culture, protein electrophoresis, western blotting, DNA and RNA analyses using real-time PCR analyses and validation of gene array analyses; daily record keeping; analyses of data; conduct literature reviews. The employee will plan experiments in collaboration with the supervisor and will be expected to independently problem solve and implement changes necessary to ensure success of the work.
Mouse work – 15-20%: Assisting/performing monitoring mice, measuring tumor growth and imaging athymic mice during experiments, weighing mice and administering treatments to mice, harvesting and processing of tumors, lungs and bones of mice and analysis of metastases.
Lab administration and maintenance – 15%: General lab maintenance, ordering laboratory chemicals and supplies, hazardous waste management, stocking of lab & tissue culture, making solutions, routine lab upkeep, and literature reviews and preparing research summaries.
Orient and Train – 5%: Assist in the training of incoming lab members, including undergraduate students and maintain lab safety and training records.
All required qualifications must be documented on application materials.
Bachelors degree in biology, biochemistry, or a related discipline and 1 year research experience; or a combination of related education in biology or biochemistry and biomedical research experience related to the job totaling at least five years.
Experience with cell culture of cell lines, protein electrophoresis, western blotting, isolation of RNA and PCR.
Strong verbal and written communication skills.
The selected candidate will have interest in animal models of cancer biology and use of modern molecular biology techniques. They will also be expected to demonstrate reliability, attention to detail, motivation, ability to follow protocols, work independently, and multi-task.
Experience and demonstrated technical ability in biochemical and analytical assays.
Experience with mouse handling, immunohistochemistry and fluorescence imaging or flow cytometry.
Ability to read and evaluate scientific papers; ability to write up scientific results and contribute to editing manuscripts; strong computer and organizational skills.
Internal Number: 336415
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.