This position is aimed at conducting research in a lab which focuses on structural biology and biophysics of membrane transport proteins (ion channels and transporters). The lab's overall goals are to elucidate near atomic resolution structures of multi-protein complexes, in different conformational states, using cryo-electron microscopy and determine the molecular bases of their function by combining high resolution structures with functional assays. The proteins under study critically regulate cellular homeostasis and electrical signaling in the heart and brain.
Duties include: Designing/engineering proteins amenable for in vitro structural and functional studies (molecular biology/mutagenesis techniques); Expressing and purifying proteins from heterologous expression systems; In vitro assays such as protein gel electrophoresis, western blots, liposome reconstitution of membrane proteins and flux assays, radioligand binding assays, fluorescence based interaction assays, etc.; lab managerial tasks such as upkeep of lab supplies, compliance with safety regulations, assisting with experimental design and laboratory organizational systems; keeping detailed written and organized records of experimental design, protocols, computer data analysis; and maintaining laboratory and experimental records.
Can also become involved in electrophysiology and single particle cryo-EM imaging.
With over 31,000 students, the University of Iowa is one of the nation's top public research universities, a member of the Big Ten conference and the Association of American Universities. The University of Iowa is composed of eleven colleges and is known around the world for its balanced commitment to the arts, sciences, and humanities. It is home to one of the nation's largest academic medical centers and the pioneering Iowa Writers' Workshop. The University of Iowa promotes work/life integration and is located in the casual yet cosmopolitan environment of Iowa City, widely recognized as one of the country's most livable communities.