Berkeley Lab's Environmental Genomics & Systems Biology Division has an opening for a Computational Biologist Project Scientist. The Computational Biologist will work in the ENIGMA scientific focus area to apply modern high-throughput metagenomic, ecological modeling, and analytical, biochemical, and genetic techniques to analyze a variety of microbial community data from field samples, isolates, and synthetic communities to ultimately to understand microbe-environment and microbe-microbe interactions in contaminated and pristine environments.
The Computational Biologist will participate in a computational research program to analyze experimental strategies to rapidly characterize microbial ecologies, identify microbial taxa and genomes from metagenomic data, and infer metabolic capabilities and metabolic networks in diverse microbial isolates and communities. The Computational Biologist will infer the evolutionary mechanisms by which closely related species adapt to their environments, or infer the molecular mechanisms by which microbes thrive in diverse environments and systematically define the biogeochemical controls on microbial species growth and community structure and identify novel approaches to selectively and predictably perturb complex microbial ecosystems.
The successful candidate will have experience with analysis of high-throughput metagenomic and/or genetic data, comparative genomics, and possibly pathway modeling. To meet these goals, the Computational Biologist will collaborate closely with the experimentalists in ENIGMA including working with teams doing field sampling, high-throughput genetics, and microbial ecology. This position is expected to present their findings in conferences and peer-reviewed journals in addition to identifying and acquiring extramural funding outside of DOE.
The Computational Biologist will also work on collaborative projects with non-LBL researchers including those at UC Berkeley and other institutions.
What You Will Do:
Develop solutions for analysis and characterization of non-model microbial organisms and microbial communities that require ingenuity and creativity.
Contribute to larger project goals and develop strong working relations with other ENIGMA teams on by choosing/recommending appropriate methods for experimental design and long-term project planning.
Help organize a small collaborative multi-institutional team of computer programmers, postdocs, graduate students, and undergraduates with respect to data tracking and analysis.
Independently plan and complete related projects including the following:
Develop methods in metagenomics and functional genomics to analyze microbial communities.
Apply statistical methods to test the quality of the data.
Collaborate with programmers to improve in-house software as needed.
Apply modern high-throughput analysis and characterization techniques to microorganisms with diverse respiratory and metabolic strategies.
Analyze laboratory-based functional genomic data in the context of the natural environment from which the microorganism was isolated.
Infer mechanistic insights from chemogenomic profiling and structure-activity relationships for high-throughput screening hits.
Integrate genetic and biogeochemical data to gain mechanistic insights into the metabolic and trophic structure of microbial ecosystems.
What is Required:
2-3 years of relevant experience in microbiology, microbial functional genomics, and high-throughput data analysis, particularly anaerobes beyond the highest customary degree.
2-3 years of experience in computer programming and computer-aided design (depending on experimental or computation emphasis).
Demonstrated experience in managing multiple projects in parallel and in corresponding with scientific collaborators.
Demonstrated success in the publication of high-impact work in internationally recognized peer-reviewed journals.
Knowledge of analytical chemistry and basic techniques like GC-MS and LC-MS.
Strong organizational and record-keeping skills.
Effective interpersonal skills and demonstrated ability to work in a team environment with a diverse group of scientific and technical personnel.
Strong written and verbal communication skills.
Additional Desired Qualifications:
Ph.D. in Computational Biology, Bioinformatics, Genomics, Genetics, Microbiology, Chemistry, Biochemistry, Chemical Biology, or equivalent experience.
Experience with alternate assays for measuring gene expression efficiency, such as GCMS analysis of metabolites, growth curves with B-gal assays, GFP assays, etc.
The posting shall remain open until the position is filled, however for full consideration, please apply by close of business on May 23, 2020.
This is a full time, 1-year term appointment that may be renewed to a maximum of five years.
M-F, exempt (monthly paid) from overtime pay.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at: West Berkeley Biocenter (Potter St.) -- Bldg. 977, 717 Potter St., Berkeley, CA.
Learn about us!
Environmental Genomics and Systems Biology
Mission:Linking genome biology to ecosystem dynamics.
Vision: Sustainable solutions to energy and environmental challenges developed through a mechanistic understanding of ecosystem dynamics.
Approach:We develop systems-level models using integrated molecular observation and controlled manipulation of model organisms and defined biomes to design and test interventions that promote beneficial outcomes.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, a retirement program that is second to none, and outstanding development opportunities. To view information about the many rewards that are offered at Berkeley Lab- Click Here.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law.
Lawrence Berkeley National Laboratory encourages applications from women, minorities, veterans, and other underrepresented groups presently considering scientific research careers.
Internal Number: 90181
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.