The laboratory of Dr. Ritchie Ho is recruiting a Postdoctoral Scientist who shares our research interests in modeling age-related diseases, particularly in neurodegenerative conditions such as amyotrophic lateral sclerosis and Huntington's disease. The Ho Lab aims to develop faithful models of late-onset diseases using human induced pluripotent stem cells (iPSCs) and in vivo, animal models by understanding and recapitulating how genetic and environmental conditions causing disease in older adults interact with intrinsic cellular aging pathways. The current goals of the lab are to 1) map the intersection of tissue and cell type-specific maturation and aging signatures to neurodegenerative signatures, 2) delineate conserved and divergent gene expression networks among human and rodent species, and 3) engineer strategies that can accelerate maturation, aging, and late-onset disease readouts in all systems. Faithful aging models will advance the development of predictive diagnostics and preventive therapies for individual patients predisposed to these diseases. To learn more about the Ho Lab, please visit: https://ritchieholab.com. We are a newly appointed research group in the Center for Neural Sciences and Medicine at Cedars-Sinai Medical Center in Los Angeles, California, with joint appointments in the Board of Governors Regenerative Medicine Institute, the Departments of Biomedical Sciences, and Neurology. We regularly collaborate with other scientists in academia as well as industry to increase the impact of our work as well as foster future professional networks.

• Mammalian tissue cultures, specifically the maintenance and directed differentiation of human and mouse pluripotent stem cells
• Cytological and histological analysis through microscopy
• Molecular biology experiments including bacterial cell culture, nucleic acid and protein extraction, cloning, library preparation for next generation sequencing, computational processing and analysis of genome scale data including bulk and single-cell or single-nucleus ATAC-seq, ChIP-seq, RNA-seq, or proteomics
• Occasional assistance with mouse handling, colony maintenance, behavioral analysis, and necropsy may be required, as well as molecular and histological analysis of mouse and human postmortem tissue
• The scientist will receive all necessary training and approval documented in IACUC and IRB protocols.