A postdoctoral position is available in the Carman laboratory at the Rutgers Center for Lipid Research at Rutgers University. The laboratory utilizes molecular genetics and biochemical approaches to study the regulation of lipid synthesis using the model eukaryote yeast. The research will focus on the Nem1-Spo7/Pah1 axis, a phosphatase enzyme cascade that regulates whether the lipid precursor phosphatidic acid (PA) is used for the synthesis of membrane phospholipids or the storage lipid triacylglycerol. The goal is to identify structural determinants of Pah1, Nem1, and Spo7 for the protein-membrane and protein-protein interactions required for the axis function of catalyzing the conversion of PA to diacylglycerol. The ultimate goal is to identify effector molecules to ameliorate lipid-based diseases such as obesity and lipodystrophy. The applicant is expected to have expertise in biochemistry and/or molecular biology. Assist the principal investigator in: 1) conducting research projects aimed at elucidating gene/enzyme mechanisms for the control of lipid metabolism; 2) preparing research reports and manuscripts for publications in journals; and assisting in preparation of research protocols and proposals; 3) keeping the workplace and laboratory organized in a clean and safe manner in accordance with established procedures and maintaining lab instruments in operational condition; 5) assist in training students through various laboratory related activities. The position will have the authority to amend and develop novel procedures and protocols as needed for the laboratory research program.
Additional information about the Carman laboratory that includes reprints of recent publications is found at http://foodsci.rutgers.edu/carman/index.html
Minimum Education and Experience:
PhD. degree in molecular biology/genetics, biochemistry, or related discipline. Expertise in basic molecular biological and biochemical techniques as documented in scholarly publications. Proficiency in oral and written English and excellent communication skills.
Required Knowledge, Skills, and Abilities:
Requires expertise in basic molecular genetics and biochemical techniques including PCR mutagenesis, DNA and RNA analyses, protein isolation, enzyme assays, column chromatography, TLC, electrophoresis, immunoprecipitation and immunoblotting.
Will use all of the typical laboratory equipment for biochemical, cellular and molecular biology experiments. Will use Excel spreadsheets, Word processing software, and graphing and statistical analysis software.
Posting Number: 20FA0171
Location: Cook (RU-New Brunswick)
Internal Number: 111670
About Rutgers University
Rutgers, The State University of New Jersey, is a leading national public research university and the state's preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities. As it was at our founding in 1766, the heart of our mission is preparing students to become productive members of society and good citizens of the world. Rutgers teaches across the full educational spectrum: preschool to precollege; undergraduate to graduate and postdoctoral; and continuing education for professional and personal advancement. Rutgers is New Jersey's land-grant institution and one of the nation's foremost research universities, and as such, we educate, make discoveries, serve as an engine of economic growth, and generate ideas for improving people's lives.