Researcher 5 position is available in the Deng lab at The Hormel Institute, University of Minnesota.
The Deng lab focuses on studying whether and how the genetic changes identified in cancer patients contribute to tumor initiation, progression and metastasis using genetic engineered mouse models; discovering novel small molecular compounds that selectively target human cancer cells while sparing normal cells; and mechanism-based repurposing drugs for cancer therapy. We have been utilizing multiple approaches including genome editing technology (CRISPR-Cas9), X-ray crystallography and Cryo-EM to functionally and structurally understand how oncogenes-driven cancer cell metabolism are selectively activated in situ in tumorigenesis. We have established a strong collaborative team that brings together expertise from the areas of cancer biology, medicinal chemistry, structural biology, pathology, and preclinical genetic mouse models to practical therapeutic studies aiming to identify the Achilles’ heel of cancers that can serve as a means to selectively and effectively kill tumor cells. The Deng lab is well founded by NCI/NIH, and our scientific findings/discoveries have been published in peer-reviewed journals such as PNAS, Genes & Dev, EMBO J, Cell, Nature, Nature Reviews Cancer, Cell Reports, EBioMedicine, Nature Columniations and Nature Cell Biology.
Duties/Responsibilities: As a research scientist of our group, the candidate would be expected to be a leader, both intellectually and in the lab. The candidate would be expected to work on multiple aspects of one or more projects at any one time. This will include, but is not limited to, experimental design, implementation and data collection as well as the analysis and dissemination of research data. The individual would be expected to work independently but also to frequently collaborate with other lab members as well as scientists at other institutions. As an integral part of our research team, the candidate would be expected to help us to maintain a safe and professional work environment at all times, and to actively participate in regular group meetings.
Job Duties: 75% Within the predetermined research scope and methodology, design and conduct experiments, collect and analyze data, and disseminate results in accordance with the research goals of the lab
10% Assist with training other lab members in specialized techniques and with the development and implementation of experiments
5% Lab maintenance and organization, including equipment maintenance and general lab cleanup
10% Other duties as assigned including, but not limited to, assisting the PI with research-related or administrative tasks and attending and presenting at scientific conferences.
Ph.D. degree in Cellular and Molecular Biology, Biochemistry, or related field with 1 or more years of training.
• Strong background and training in cancer biology, biochemistry, and experimental studies utilizing genetically engineered mouse models for cancer studies or a related field.
• Strong organization skills as well as strong written and verbal communication skills in English.
• Previous mentoring and lab leadership experience is highly preferred.
• The candidate must be able to effectively manage research projects with little oversight from the PI, and assist the PI with oversight of the lab’s research endeavors.
• We are particularly interested in a candidate that is enthusiastic, self-motivated, keen to learn, and able to thrive in a highly collaborative and multi-disciplinary research environment.
Internal Number: 335104
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.