Research - Laboratory/Non-Laboratory, Staff/Administrative
Life Science Research Professional 2
Job Number: 85888
Grade: G FTE: 100% FTE The Davis lab at Stanford School of Medicine is seeking a highly motivated, collaborative and well organized Life Science Research Professional 2 with experience in in vivo experimentation to support our work in identifying and targeting relapse causing cell populations in childhood leukemia. Our laboratory is interested in understanding the fundamental mechanisms and cellular species that enable relapse in childhood cancer, primarily in leukemia. To do so, we utilize high dimensional single cell platforms, including mass cytometry, to profile primary human tumor tissues and identify cellular subpopulations associated with clinical outcomes of interest. Our laboratory seeks to develop improved prognostic tools and develop improved strategies for therapeutic targeting of relapse associated cellular species. In vivo experimentation is critical for the development and assessment of leukemogenic potential of candidate cell populations, for expansion of cellular populations and for testing therapeutic strategies to target these cells. Primary responsibilities linked to this position are to develop animal models of these leukemias, perform limiting diluation assays to assess potency and assess efficacy of diverse therapies under development in the lab. Also, the maintenance of mice colonies, design and conduct in vivo experiments and provide technical assistance to other researchers performing in vivo experimentation. Other job duties include maintaining excellent lab records and animal inventory, report weekly to supervisor, effectively communicate experimental results to the team and the principal investigator, and train other lab personnel on basic animal experimentation techniques.
Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
Contribute substantially to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
Work with health and safety department to ensure lab complies with regulations and all required trainings.
Serve as a technical resource for other research staff; train staff or students as needed, including direction on techniques, as well as consultation on project work.
Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general managerial lab support as needed. May assist with purchasing laboratory equipment.
*- Other duties may also be assigned
Master's degree or PhD with experience in in vivo experimentation. Knowledge and experience in animal handling , sample collection and processing and colony maintenance and genotyping. Techniques required for development and engraftment of human tumors in animal models: bone marrow transplantation, intramuscular and intraperitoneal injection, orthotopic cell transplantation, in vivo imaging. Strong background in molecular biology and cell culture techniques (protein analysis by flow cytometry, western blotting and/or ELISA, cell expansion,, staining and analysis by flow cytometry).
Proficiency in scientific writing in English
Exceptional attention to detail and meticulous execution and record of experiments is essential
Must be able to think critically and is encouraged to design experiments with guidance
An understanding of biological principles
Strong communication skills
Must adhere to highest ethical principles when working with laboratory animals
EDUCATION & EXPERIENCE (REQUIRED): Master's degree in related scientific field and two years of relevant work experience KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Strong analytical skills and excellent judgment.
Ability to maintain detailed records of experiments and outcomes.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to accurately complete detailed work.
CERTIFICATIONS & LICENSES: Add here
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs.
Location: School of Medicine, Stanford, California, United States Schedule: Classification Level:
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.