Academic/Faculty, Research - Laboratory/Non-Laboratory
Assistant Project Scientist University of California Los Angeles
Requisition Number: JPF05220 Recruitment Period Open January 13th, 2020 through Thursday, Feb 13, 2020 at 11:59pm (Pacific Time)
Duties of the Assistant Project Scientist Step 2 include the design, synthesis and purification of small organic molecules that inhibit the activity of several important classes of enzymes and receptors, usually those involved in cellular proliferation and regeneration of hematopoietic stem cells. In particular, the successful candidate would have familiarity with small molecules for the treatment of various types of cancer, namely inhibitors of enzymes linked to cancer proliferation. The successful candidate will first of all design new analogues of known compounds with the goal of preparing both novel and non-obvious molecules that would allow the patenting of these substances for use in the treatment of human disease. The person chosen will carry out all of the synthesis and structure determination and provide samples of the new small organic molecules to the biologists for testing and verification of biological activity. In addition the candidate would have to have more than a passing knowledge of the underlying biology of these processes and enzyme systems. Moreover a knowledge of molecular modelling and docking of small molecules into enzyme and receptor pockets would be greatly prized. The Jung lab is a single PI, multi-disciplinary operation, involving the design of many small molecule analogues of verified lead molecules and many syntheses and structure determinations. In order to effectively run this operation, the help of a senior scientist is absolutely necessary. The successful candidate will not only work with the existing projects in synthetic medicinal chemistry, but also will extend the scope of the research to other collaborative projects at the Chemistry-Biology interface.
The Assistant Project Scientist will also be responsible for supervising graduate and undergraduate students and junior postdoctoral fellows working in this area, namely in trying to prepare truly druglike molecules for use as eventual human medicines. Thus experience in both synthesis and medicinal chemistry is required. The candidate will also be responsible for purifying and determining the structures of all organic molecules, using all spectroscopic techniques available, e.g., high-field NMR and the available modern NMR methods of analysis, mass spectrometry, and x-ray spectroscopy when appropriate.
Candidates should have a Ph.D. in organic chemistry and at least 5 years of postdoctoral experience working in the application of synthetic organic chemistry to medicinal chemistry and biological problems. Candidates should also have a proven record of publication in scholarly journals in the area of synthetic organic and/or medicinal chemistry.
The Assistant Project Scientist will report directly to the PI managing the UCLA synthetic medicinal chemistry laboratory. The successful candidate is expected to have working knowledge of all laboratory SOPs and other safety procedures, and to work with the PI and the group safety officer to maintain a safe and productive working environment.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction
UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.