We are seeking a postdoctoral fellow to join the laboratory of Mark Niciu M.D. Ph.D. in the Department of Psychiatry and Iowa Neuroscience Institute at the University of Iowa Health Care.
The Niciu lab is interested in the pathophysiology and experimental therapeutics of major mood disorders, particularly glutamate and subanesthetic-dose ketamine in treatment-resistant major depression. Another major aim is the identification, replication and dissemination of antidepressant response biomarkers. As an example, our group and others have observed that treatment-resistant depressed subjects with a family history of an alcohol use disorder in a first-degree relative have a greater and more sustained antidepressant response to ketamine. We are currently studying potential alcohol-sensitive multimodal, e.g. psychological, neurophysiological and neuroimaging, biomarkers to predict antidepressant response with greater sensitivity and specificity than family history alone. On the translational front, we use human-induced pluripotent stem cell (hiPSC)-based models, i.e. cortical-like spheroids, to study genetic, molecular and cellular mechanisms of disease and pharmacological response to racemic ketamine, bioactive ketamine metabolites and other compounds in the future.
This is a postdoctoral position of pharmacological imaging in treatment-resistant depression. We seek to identify potential treatment response biomarkers and mechanisms of rapid antidepressant response to the glutamate modulator ketamine. To this end, we perform multimodal imaging - structural magnetic resonance imaging (MRI), resting-state functional magnetic imaging (fMRI) and magnetic resonance spectroscopy (MRS) - at high-magnetic field strength (7-Tesla) with depressed subjects during medication challenge, i.e. alcohol and ketamine infusion. We are also interested in incorporating other imaging modalities in the future.
The University of Iowa, Department of Psychiatry offers competitive salary, excellent benefits, and a collegial professional environment. The University of Iowa Hospitals and Clinics has been recognized as one of the best hospitals in the United States and is Iowa's only comprehensive academic medical center and regional referral center. It was recently name by Forbes magazine as the nation's #1 employer in the health care industry, and the #7 employer overall.
Iowa City is an attractive, family friendly, college town with abundant local and world-class cultural, theatrical and musical events, top ranked schools, and outdoor recreational attractions. The Iowa City area is often ranked as one of the most livable communities in the nation (Livability.com). To learn more about our great community visit https://www.iowacityarea.com/cricnl-area/
With over 31,000 students, the University of Iowa is one of the nation's top public research universities, a member of the Big Ten conference and the Association of American Universities. The University of Iowa is composed of eleven colleges and is known around the world for its balanced commitment to the arts, sciences, and humanities. It is home to one of the nation's largest academic medical centers and the pioneering Iowa Writers' Workshop. The University of Iowa promotes work/life integration and is located in the casual yet cosmopolitan environment of Iowa City, widely recognized as one of the country's most livable communities.