The University of Maryland Baltimore (UMB), Department of Medicine, Division of Cardiovascular Medicine is currently seeking a Senior Research Analyst . The selected candidate will work as part of the "Hong Laboratory" cardiovascular research team studying chemical biology of vertebrate development. Our research program uses a variety of statistical, epidemiological, and laboratory-based methods to map variations in genes that are associated with embryonic development that may contribute to cardiac disease. We will be mining a massive data set from the UK Biobank to find these associations from hundreds of phenotypes based on clinical measurements and diagnostic codes.
The candidate will select, identify and define specific phenotypes and perform phenotype-genotype association analysis using data from 500,000 UK Biobank subjects. Specific tasks will include development of software-ready phenotype definitions based on diagnostic codes, execution of our overall analysis plans, development/modification/management of programming scripts to automate the association analysis and loading of results into our OASIS database, as well as implementation of existing/new bioinformatics programs to provide data visualizations and interpretation. Candidate must have a good understanding of biomedical sciences, a good working knowledge of both R and Plink, which are standard statistical programs used for genetic association analysis, and experience with the UNIX/LINUX operation system.
The candidate must be able to work well independently and be comfortable working in a team environment with clinicians and researchers from multiple disciplines.
UMB offers a generous benefits package that includes 22 vacation days, 14 floating and holidays, 15 sick days; comprehensive health insurance and retirement options; and tuition remission for employees and their dependents at any of the University System of Maryland schools.
Develop software-ready phenotype definitions based on electronic health record data from the UK Biobank. Interact with physician-scientists to collaboratively define phenotypes for genomic association analysis.
Manage/modify/execute UNIX scripts for batch job processing of programs for association analysis, database loading and generation of graphical visualizations to aid in interpretation of results.
Educate physician-scientist on the use of tools for understanding analysis results.
Integrate, in an iterative fashion, the biomedical/clinical suggestions, insights and understandings from early analysis runs into subsequent analyses.
Manage/coordinate the batch computer processing to optimize and prioritize the multiple research opportunities that will be identified as our research progresses.
Work closely with bioinformatics researchers across multiple disciplines to identify and define new features and/or analyses approaches to enhance cardiology research.
Provide guidance, training, and mentoring to less experience personnel in qualitative and quantitative analysis.
Perform other related duties as assigned.
Education: Bachelor's degree in Cellular Molecular Biomedical Sciences, Information Management, Social Science, Public Policy, Mathematics, Statistics, Health Science or Services or in a field of study related to the research. Master's degree is preferred.
Experience: Two (2) years related experience in a research environment required. Experience in R, SAS, STATA, SPSS, and/or Excel preferred. Experience in basic programming experience related to genomic association analysis and graphical visualizations is preferred.
The preferred candidate will have:
Experience with UK Biobank phenotypes and genotypes.
Experience working with clinicians and/or biomedical sciences professionals.
Experience with the R programming language for statistics and graphics.
Experience with the Plink toolset for whole genome association analysis.
Experience with the UNIX operating system and shell scripting.
Demonstrated ability to learn and apply new techniques rapidly and effectively.
Knowledge, Skills, and Abilities:
Solid foundation in biomedical sciences with coursework covering chemistry, biology, genetics, genomics, microbiology, cell biology, biostatistics and bioinformatics.
Basic understanding of mechanisms and research processes used in biomedical science research such as animal models, PCR, enzyme digestion, stem cell cultures and cloning experiments.
Knowledge of ethical considerations related to human subject research.
Knowledge of genomics and bioinformatics tools and techniques.
Understanding of phenotype-genotype association analysis.
Knowledge of basic statistical concepts, including experience with linear regression and analysis of variance.
Ability to effectively operate analysis software and manipulate data in a UNIX environment.
Able to document and describe routine processing.
Ability to work interactively in a small group setting with project investigators and other key personnel essential.
Strong analytical skills and the ability to effectively solve problems within the scope of the position.
Ability to design and recommend changes to research projects and/or area of technical specialty.
Ability to learn additional computer skills quickly.
Excellent oral and written communication, presentation and interpersonal skills.
Hiring Range: Commensurate with education and experience
If accommodations are needed for a disability, please contact Staffing & Career Services at 410-706-2606, Monday - Friday, 8:30am - 4:30pm EST. Maryland Relay can be accessed by dialing 711 (in-state) or 1-800-735-2258.
Equal Opportunity/Affirmative Action Employer. Minorities, women, protected veterans, and individuals with disabilities are encouraged to apply.
Job: Reg or CII Exempt Staff - E3322D
Employee Class : Exempt Regular
Full Time/Part Time: Full-Time
Shift: Day Job
Financial Disclosure: No
Organization: School of Medicine - Department of Medicine
Job Posting: Dec 2, 2019
Unposting Date: Dec 10, 2019, 4:59:00 AM
Internal Number: 140101
About University of Maryland, Baltimore
The University of Maryland, Baltimore (UMB) is the State's public health, law and human services university devoted to excellence in professional and graduate education, research, patient care, and public service. As a diverse community of outstanding faculty, staff and students, and using state-of-the-art technological support, we educate leaders in health care delivery, biomedical science, global health, social work and the law. We emphasize interdisciplinary education and research in an atmosphere that explicitly values civility, diversity, collaboration, teamwork and accountability. By conducting internationally recognized research to cure disease and to improve the health, social functioning and just treatment of the people we serve, we foster economic development in the City, State, and nation. We are committed to ensuring that the knowledge we generate provides maximum benefit to society and directly enhances our various communities.