Posting Summary: The Bushweller Laboratory in the Department of Molecular Physiology and Biological Physics at the University of Virginia seeks a Research Associate. The successful candidate will perform research in structural biology of protein-RNA interactions and various small molecule screening efforts targeting transcription factors. The laboratory is interested in understanding the role of RNA binding in regulating critical regulators of blood cell development, hematopoiesis, and leukemia. This person will also contribute to efforts to develop small molecule inhibitors of transcription factors that are targets in leukemia. The project requires a combination of techniques from molecular biology, protein crystallography, NMR spectroscopy, screening, and biochemistry.
The initial job duties for this person will be completing PAR-CLIP studies to identify the RNA targets of selected proteins in cells. Subsequently, the structure of protein-RNA complexes will be determined using either X-ray crystallography or NMR spectroscopy. This person will also be carrying out small molecule screens with target transcription factors using fluorescence based methods and characterizing the ligand-protein interactions using NMR spectroscopy and X-ray crystallography. This person will also be responsible for training graduate and undergraduate students. The successful candidate will have access to state-of-the-art crystallography and NMR-spectroscopy facilities.
The highly motivated candidate must have a Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field by appointment start date. Candidates must have at least one publication in a peer-reviewed journal, extensive experience in cloning and protein expression and purification, and should have a basic knowledge of protein crystallography and NMR spectroscopy. The ability to work independently yet to interact well with a diverse group of scientists and students is essential.
To apply visit jobs.virginia.edu and search for posting #0624517. Applicants should complete a candidate profile through the Jobs@ website and provide a cover letter, CV, and a list of three references.
Contact Dr. Bushweller with questions regarding the position at firstname.lastname@example.org, or Scott Kozuch with questions regarding the application process at email@example.com.
The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans and persons with disabilities are encouraged to apply.
Internal Number: 353_86063
About University of Virginia
Founded by Thomas Jefferson, the University of Virginia opened in 1825 as the nation's first public university. A longstanding dedication to preeminence in both scholarship and teaching; top ranking in global satisfaction, collegiality and work/family issues on the COACHE survey of early career faculty; a commitment to excellence that is integrally connected with diversity and a broad array of benefits make the University of Virginia a prime choice for both faculty and staff. The University of Virginia is located in the small cosmopolitan city of Charlottesville near the Blue Ridge Mountains, 70 miles from Richmond and 110 miles from Washington, D.C. The University of Virginia remains the No. 2 best public university in the 2013 edition of the U.S. News and World Report rankings. In the 14 years since U.S. News began ranking public universities as a separate category, U.Va. has ranked either No. 1 or No. 2. U.Va. continues to rank in the Top 25 among the best of all national universities, public and private.