Salary Range: Dependent on Qualifications/Experience
The full time (40hours week) senior research associate position will assist the principal investigator in directing and managing a pre-clinical research program related to discovery and clinical translation of cancer associated antigens. Work will include biological validation of antigens that are predicted using computational genomics, as well as planning, performing, and supervising others in performing experiments designed to test the utility of predicted antigens as immunotherapy targets. Specific duties will include (1) assisting in planning, conducting, and reporting on T cell culture, mass spectrometry, and next generation sequencing experiments; (2) management of cell line and tissue-derived hematological malignancy sample banks, including oversight of collection and processing of clinical samples; (3) generation of antigen specific T cell cultures and performing single cell transcriptome and T cell receptor profiling; (4) immunoprecipitation of peptide/MHC complexes with recovery of MHC bound peptides for analysis by mass spectrometry; (5) single cell T cell functional studies; and (6) management of 1-3 other personnel who will assist with data generation and reporting.
Education and Experience:
Specific professional experience should include at least 5 years of prior employment in a basic and/or translational science laboratory. Prior experience should include: (1) ability to assist in planning, conducting, and reporting research, including experimental design, results interpretation, writing methods sections for grants and manuscripts, creating figures and tables for presentation and performing focused literature searches; (2) experience with biospecimen storage and handling; (3) basic laboratory skills (preparation of solutions, dilutions of common reagents, etc); (4) experience with nucleic acid extraction, PCR, mammalian tissue culture, gene expression and protein-expression assays; (5) exceptional organizational skills, communication and record keeping.
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.
Internal Number: 171323
About The University of North Carolina at Chapel Hill
Carolina rates among the nation’s great institutions of higher education, set on an historic and beautiful campus that celebrates all four seasons. Carolina’s students, faculty and staff come here from around the world, bringing varied cultural, racial and ethnic heritages that help make UNC-Chapel Hill a thriving intellectual center. We’re repeatedly ranked the nation’s best value in higher education for students seeking to earn a college degree – the University has garnered the top spot each time since the ranking’s launch in 1998.Whether you’ve just started your career, are new to academia or are a seasoned professional with assorted campus experiences to draw on, we hope you will find a great place at Carolina.