The candidate will work independently under the supervision of the principal investigator to develop and test novel treatments using AAV-mediated gene replacement therapy, gene editing therapy and dystrophin-independent, disease-mechanism-based gene therapy to treat Duchenne muscular dystrophy (DMD) in canine and murine animal models. Further, the candidate must be highly proficient in the following areas of responsibility:
Design, execute and lead studies independently to test novel treatment in canine and murine DMD animal models.
Manage a canine DMD model colony. This includes, but not limited to, initiate, (breed and whelp), maintain, care and manage a dog colony.
Study the natural history of the canine DMD model.
Investigate DMD pathogenicity and mechanism in animal models.
Immune response (innate, T cell and B cell response) evaluation prior to and after drug or gene therapy.
Develop novel assays to evaluate the mechanical function of skeletal muscle in both canine and mouse DMD animal models.
Independently perform sedation and general anesthesia procedures in canines.
Independently perform gross and micro surgical procedure in canines.
Perform invasive and noninvasive muscle force measurement in canines, and gait analysis and whole-body mobility assay.
Independently perform ultrasound guided gene delivery to selective muscles in canines.
Independently perform muscle biopsy and necropsy in animal models.
Mentor graduate students and postdoctoral research associates to design research projects and troubleshoot problems in experimental techniques.
Write progress reports of the project, manuscripts, and grant proposals. Present data at scientific meetings.
Ph.D. in Microbiology, Immunology, Gene Therapy, or a related field with focus in Gene therapy; must have at least 5 years of productive postdoctoral experience. Successful applicant should be fluent in commonly used molecular and cellular biology techniques such as PCR, qPCR, western blot, histochemical staining, immunostaining, and bright-field, fluorescence, confocal, and electron microscopy. Applicant will also have extensive experience in muscle biology, muscle physiology, muscular dystrophy, gene therapy vector, adeno-associated virus (AAV) vector production, purification and quality control; immune response to viral gene therapy and in vivo gene therapy in animal models (both rodents and large animals). Good communication and teamwork skills are essential.
Be prepared to upload a cover letter, CV and list of 3 references with contact information.
This position is eligible for University benefits. The University offers a comprehensive benefits package, including medical, dental and vision plans, retirement, and educational fee discounts. For additional information on University benefits, please visit the Faculty & Staff Benefits website at http://www.umsystem.edu/totalrewards/benefits
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