Cures Start Here .At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Hingorani Laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based treatment strategies. Our ultimate aim is to take our discoveries and reduce them to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.
This Research Technician II/III position represents an excellent opportunity for an experienced, highly motivated individual with a passion for science to work and learn in a dynamic scientific environment while addressing important problems relevant for the successful treatment of cancer.
The research technician will be involved in all aspects of murine preclinical studies including but not limited to breeding, genotyping, ultrasound and other imaging techniques, drug treatments, and performing necropsies to obtain tissues for histology and cell lines. The technician may be involved in derivation, maintenance and study of primary cell lines; isolation of DNA, RNA, and proteins; as well as other techniques such as FACS sorting and expanding cells in vitro, analyzing cell phenotype and function using techniques including flow cytometry, proliferation assays, cytotoxicity assays, PCR, RT-PCR, sequencing, and ELISpot. Molecular techniques used in the lab include cloning, transfection/transduction of cell lines, gene targeting and northern and Southern blotting. Biochemical and cellular techniques include SDS-PAGE, western blotting, immunofluorescence, and immunohistochemistry. The technician will also assist with the management and organization of a fast-paced lab, and perform other duties as assigned by supervisor
A bachelor's degree in bioengineering, biophysics or biological sciences and at least 5 years of laboratory research experience including small animal surgeries and injections, cell tissue culture, flow cytometry, and molecular biology techniques are required.
A master's degree in a biological field and at least 2 years of experience in the techniques listed above are highly desired.
Computer skills: Microsoft Excel, Prism (Graphpad), FlowJo, and statistical programs for data analysis
Excellent organizational and interpersonal skills are required.
Strong troubleshooting skills and the ability to multi-task with precise attention to detail is especially critical.
Experience with genetically engineered murine models of pancreas cancer or other solid tumors is desired.
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.