The Kraemer laboratory seeks a motivated individual who works well with others to join a multi-disciplinary collaborative research team as a Postdoctoral Scholar focused on the molecular genetics of aging associated neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, and related dementia disorders.
We are investigating the molecular mechanisms of aging induced protein aggregation and neurodegeneration using forward genetic approaches. Specifically, we have identified many genetic suppressors of the neurodegenerative phenotypes caused by transgenic human tau and TDP-43 protein expression in C. elegans neurons. We have identified several intriguing candidate genes involved in RNA processing that are ripe for a new postdoctoral researcher to translationally characterize further using behavioral, genetic, and biochemical analyses. By completing these studies, we aim to nominate novel therapeutic target genes for translation studies in rodent models of neurodegenerative disease.
Desirable experience/knowledge/skills include:
Experience in molecular cloning
Experience in transgenesis methods or genome editing using CRIPSR/Cas9 methods.
Experience with genetic analysis methods in model organisms.
Experience in assessing protein aggregation.
Experience in advanced microscopy techniques.
Knowledge of the pathobiology of neurodegenerative disease
Knowledge of the biology of aging and disease
Knowledge of neurobiology
Skill with nematodes as a model organism
Skill with Mice as a model organism
Skill with cell culture models of disease.
Anticipated start date is February 2020
Postdoctoral scholars are represented by UAW 4121 and are subject to the collective bargaining agreement, unless agreed exclusion criteria apply. For more information, please visit the University of Washington Labor Relations website.
A recent PhD in a relevant field of the biomedical science.
Experience designing and executing well controlled experiments.
Strong writing skills.
Strong verbal communication skills.
Ability to work both independently and as a cooperative part of a team.
US citizenship or permanent resident status.
Submit CV and Cover Letter outlining specific experience via the Interfolio link provided.
Application review will continue until the position is filled.
Questions about this position by be directed to Brian Kramer, PhD, firstname.lastname@example.org
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University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information, gender identity or expression, age, disability, or protected veteran status.
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