Research - Laboratory/Non-Laboratory, Staff/Administrative
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The Department of Biochemistry at the University of Washington has contributed to many phases of research. Initially recognized for incisive studies of the structure and function of proteins, and the mechanisms of enzyme action, the department branched out into a multitude of other areas. These included: developmental biology of flies, fish, frogs, and mice; molecular mechanisms of aging in yeast and mammals; vertebrate visual and immune responses; chromosome dynamics, cell division, DNA replication and repair; energy transduction during photosynthesis; protein secretion and membrane fusion; translational control and regulated protein degradation; protein structure determination by crystallography and NMR spectroscopy; and protein structure prediction and enzyme design. Our diversity of interests guarantees a rich intellectual and educational environment.
About the Institute for Protein Design: The Institute for Protein Design (IPD) at the University of Washington in Seattle is creating a new world of synthetic proteins to address 21st-century challenges in medicine, energy, and technology. The IPD is a unique interdisciplinary environment where world-class researchers with expertise in computing and software, biochemistry, genome sciences, biological structure, pharmacology, immunology and other basic science disciplines, as well as clinical medicine, work together to both computationally design and experimentally characterize novel biomolecules. Current projects include the design of novel therapeutics for cancer, neurological diseases, and more, as well as new vaccines, nanomaterials, and enzymes.
The Institute of Protein Design within the Department of Biochemistry currently has an outstanding opportunity for a RESEARCH SCIENTIST 3.
The field of research that this postion Research Scientist / Engineer 3 (RES3) in Computer Science is engaged in software engineering of machine learning (ML) algorithms and Rosetta code (including GPU accelerated code) for molecular modeling, protein structure prediction and design. For more detailed information about the Institute for Protein Design please see http://www.ipd.uw.edu/.
The RES3 is a key position within the Institute for Protein design, and will be directed at greatly improving the efficiency of Rosetta computational protein structure prediction and protein design.
The RES3 position will perform software engineering of specific machine learning (ML) algorithms and Rosetta code for use in GPU accelerated computing. The research activities involves optimization of protein structure prediction with broad range utility for improving the Rosetta molecular modeling and design algorithms for the de novo computational protein design.
The primary responsibilities of the RES3 are:
Develop new machine learning algorithms for protein structure prediction and design.
Communicate with the Rosetta community to solicit and address feedback.
Collaborate with other research staff, postdoctoral fellows and graduate students on computational protein structure prediction and de novo protein design.
Participate in projects with uncertain outcomes requiring analysis from multiple perspectives.
Trains others in how to use Rosetta software and protein design computing infrastructure.
Manages complex multi-task projects directed at improving computational protein structure prediction and design.
Uses expert knowledge and judgment to develop new methods and tools for protein structure prediction and design.
In this role, ~90% of the effort will be dedicated to computational algorithm development for protein structure prediction and design. The remaining ~10% of effort will be dedicated to preparing technical reports, publications in scientific journals and presenting project results to stakeholders.
Doctoral Degree in Biochemistry, Computational Biology or Computer Science + 3 or more years of experience in related field.
Computational protein structure prediction and design with Rosetta, development of machine learning algorithms for protein structure prediction, various software languages and data base architectures, ability to work independently and in teams.
Deep learning algorithm development, Network development, Cross-platform (Linux/Windows/macOS) development, Experience in computational protein structure prediction, and design with Rosetta molecular design and modeling algorithms
Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.