Research Associate (Postdoc) to work in Marcia Gordon's biomedical research laboratory on causes and treatments of Alzheimer's disease. Pay scale will be equal to NIH NRSA awards depending upon years of experience. Seeking highly motivated individual with capability of working independently. Applicant will also be trained in grant writing and managing an NIH funded research laboratory.
This position will work on an NIH funded project to understand the role of cellular senescence in modulating the pathologies found in the Alzheimer's disease brain. This project will use existing mouse models of tauopathy and amyloid deposition. Aims of the project will elucidate which cellular subtypes become senescent in mouse and human brain and examine the role of lifespan extension and senolytic drugs on the extent of tau pathology in mice of different ages. Some of the studies will require small animal surgeries, experiments in cultured cells and production of adeno-associated viral vectors. Measurements will include assessments of mouse behavior, analysis of histological sections, and neurochemical measures of markers of pathology and inflammation. The laboratory is located in a new research center, very well equipped with new instrumentation including a Zeiss Axioscan digital scanning microscope. a Biorad Chemidoc Gel imaging systems, a Quanterix Simoa automated Elisa instrument, a mouse behavior core facility, and a shared Thermo Scientific LC/MS core. In addition to laboratory research, the fellow will be mentored in research grant development, the ability to manage multiple projects simultaneously and the supervision of 2 or more personnel working on your projects. Training will also be provided in how to develop 1 hour lectur for scientific and educational purposes.
The position requires a doctoral degree in a biomedical research discipline which included at least 4 years of experience in a research laboratory.
Individual should be familiar with common biological laboratory research practices and have a basic understanding of biochemistry, molecular biology, cell biology and physiology.
Applicants should be experienced with being able to conduct research studies independently, scientific record keeping, collections and analysis of figures and tables, fundamental statistical analysis, and the format of preparing results for publication as a scientific manuscript.
Good command of spoken and written English is a requirement.
Training in the discipline of neuroscience is highly desired.
Past experience in the field of Alzheimer's research is also highly desired.
Experience with some or all of the following techniques will also be desired: flow cytometry; cell sorting; testing of mouse behavior; tisssue collection techniques such as brain dissection, blood collection, CSF collection; histological sectioning, staining and analysis; neurochemical measurements by western, northern, Southern blotting, ELISA methods; small animal surgery techniques, especially intracranial injections; molecular biology techniques such as cloning and viral vector production, PCR techniques; cell biology techniques such as transient transfections, development of stable transfected cell lines, differentiation of iPSCs into neural cell types.
Ability to analyze big data sets from methods such as RNA Seq or Mass spec based proteomics would also be desirable.
Required Application Materials
Curriculum Vitae, Names of 3 references, 1-2 page statement highlighting past accomplishments and stating goals for the next 10 years.
Review of Applications Begins On
Summary of Health Risks
Work with animals or unfixed animal tissue
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