Cures Start Here. AtFred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first and largest cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We are looking for a highly motivated individual to support the development of immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity to cancer. The technician will be closely involved in the preclinical development of new TCR-based therapies and their translation into clinical trials. The candidate should be capable of maintaining detailed laboratory records, analyzing data, and reporting experimental results.
The technician will assist in the design, implementation and interpretation of experiments involving human T lymphocytes engineered to target tumor cells. These studies are specifically aimed at identifying ways to increase the therapeutic activity of tumor-reactive T lymphocytes.
Perform tissue culture and molecular biology techniques: Generation of antigen-specific T cells, transduction with retroviral and lentiviral vectors, FACS sorting and expanding cells in vitro.
Analyze T cell phenotype and function using techniques including flow cytometry, proliferation assays, PCR, RT-PCR, sequencing, and T cell cytolytic assays.
Some murine work may be necessary in the future, with the assistance of dedicated murine technicians
Assist with the management and organization of a fast-paced lab. Other duties as assigned by supervisor will be performed as necessary including conductingliterature reviews to assist in determining most suitable methods to be used in research.
Contribute to the preparation and presentation of written or oral progress reports concerning studies and assist in publication of results.
Tech I level: A bachelor's degree in a biological field and prior laboratory research experience
Tech II level: A bachelors degree in a biological field and two years or more of post-bachelors laboratory research experience
To succeed in this position candidate must enjoy working independently but be able to interact well in a team environment.
Excellent organizational and interpersonal skills, the ability to multi-task, and attention to detail are critical.
Immunology background with experience in aseptic cell culture techniques, multi-color flow cytometry and in establishing and maintaining primary human T cells is preferred.
Masters degree providing immunology training and/or relevant technical expertise a plus.
Computer skills: Microsoft Excel, Prism (Graphpad), FlowJo and statistical programs for data analysis.
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.