Research - Laboratory/Non-Laboratory, Staff/Administrative
As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world. UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a "Great College to Work For" for four consecutive years.The University of Washington, Department of Pathology is a broad and dynamic department that strives for a consistent level of high achievement in all of its activities. The Department offers full diagnostic services in all areas of Pathology, is a top ranked research organization as measured by research awards from the National Institutes of Health, and offers an array of specialized educational training programs.UW Medicine Pathology brings together state-of-the-art technology and highly trained, world renowned personnel to provide comprehensive diagnostic and personalized service to physicians, community hospitals, independent laboratories, and other health care organizations. Our operations are based at the University of Washington Medical Center, Harborview Medical Center, South Lake Union, Northwest Hospital and the Seattle Cancer Care Alliance. Pathology faculty members also serve at Seattle Children's Hospital, the Veteran's Administration Puget Sound Healthcare System, and the Fred Hutchinson Cancer Research Center. These collaborative efforts have generated innovative, translational studies in the basic mechanisms of disease as they apply to diagnostic pathology.The UW BioRepository and Integrated Neuropathology (BRaIN) Research Laboratory has an outstanding opportunity for a Full Time Research Scientist 3. This is an excellent opportunity for the scientist to participate in research activities primarily associated with quantitative assays associated with human brain tissue and cells with additional opportunity to participate in human research brain examination including brain removal, dissection, preservation, and processing, and complex procedures for services such as histology, brain autopsy, and/or specialized quantitative fluid and tissue based assays. Under the general supervision of the Principle Investigator, the research scientist 3 will manage a moderate size project with broad scope, the multiplex tissue-extraction-based immunoassay program, which serves several funded grants and crosses multiple critical projects to understand the quantitative neuropathological changes associated with neurodegeneration and neurotrauma. The successful applicant, working with direction from the PI for overall project objectives, will use his/her technical expertise and broad knowledge of principles of antibody binding and solution phase multiplexed assays to develop and maintain quality control standards, ensure project goals and deadlines are met, and troubleshoot complex problems as they arise. He/she will primarily perform human tissue protein extractions, protein measurements, and targeted and multiplexed immunoassays to determine molecular changes associated with neurodegeneration, neurotrauma, and dementia. In association with this critical position managing and performing this important research, the successful applicant will contribute to reporting of methods and data through presentations and publications, potentially as co-author, and lead team members to ensure flexibility and coordination as research needs change and hypotheses evolve. The RS3 role in this and other projects will be critical through effecting planning, leadership, knowledge, and experience to help drive the science through internal and external collaboration, ultimately including local and national recognition for the advancements and their influence on our understanding of critical brain injuries and disease.In addition, the research scientist 3 may participate in/provide support for other laboratory projects, which may include tissue clearing and staining for three dimensional microscopic reconstructions of brain injury and disease, in silico 3D reconstructions of microscopic and gross brain images, participation in slide scanning and image analytics, tissue processing for analysis by mass spectrometry and chromatography techniques, and other tissue analytics.Opportunities to participate in human cell culture projects and work with invertebrate animal model systems may be available. Specimen preparation for and application of molecular analysis of human tissues, cells, and biofluids with respect to RNA and DNA applications including single cell profiling may be available. Finally, opportunities to participate in the Precision Neuropathology (PNP) Core activities associated with research brain autopsies including brain removal, dissection, preservation, and analysis, in addition to support for histology and immunohistochemistry applications, are common. The successful applicant will monitor the work of others on his/her team and be responsible for training and direction and, if needed, redirection as the projects develop. He/she will be required to use care and maintain instruments; perform quality control and quality assurance; perform research and assist in development of new procedures; monitor reagent use, and perform preventative maintenance on instruments according to prescribed protocols. The successful applicant will be expected to organize and maintain updated laboratory notebook and databases on research projects and to navigate the laboratory and pathology computer networks, participate in lab and other meetings, provide regular progress updates, review work lists and prioritize work in conjunction with the PI and BRaIN lab leads, and interact with the research team and collaborators. For additional compensation, after hours call for research brain autopsies may be available, although participation in this aspect of the BRaIN lab is highly competitive. Finally, the research scientist will be expected to assist with a variety of special projects, and research related duties as assigned in a research environment where innovation and novel analytic applications form the foundation of an integrated model of precision neuropathology.This position has operational access to patient health information and clinical materials including pathology specimens and archival blocks and slides, and for these activities must adhere to the covered entity HIPPA Privacy and CLIA rules and has 'dotted line' reporting to the CLIA certificate holders and applicable clinical laboratory management staff.Minimum Requirements:Minimum education requirement of a Bachelor's Degree with coursework in chemistry, biology, other biological sciences.Minimum of 3 years' experience in a related area or equivalent combination of education and experience; some or all may be in relevant educational programs.Appropriate experience in appropriate field(s) of research is necessary.Desired:Experience with any or all of the following: Immunohistochemistry, immunofluorescence staining, protein assays and solution phase immunoassays, molecular applications including tissue and single cell RNA and DNA sequencing, brightfield or fluorescence microscopy. Conditions of Employment: UW Research Scientists are essential to BRaIN research laboratory activities; this position may occasionally require work after-hours, weekends and or outside normal business hours. Application Process:The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.