A Postdoctoral Research Associate position is available in the Department of Cellular and Integrative Physiology at the University of Nebraska Medical Center to investigate cell surface glycoproteins and glycans in a variety of biological contexts, including stem cell differentiation, heart disease, and cancer. The laboratory uses state-of-the-art mass spectrometry and bioinformatic methods to study cell surface glycoproteins and glycans for the purpose of developing new reagents for immunophenotyping, immunotherapy, and targeted drug delivery. Excellent funding, analytical infrastructure with state-of-the-art mass spectrometry (Thermo Eclipse and Exporis with FAIMS) and software are in place. The successful candidate will have the opportunity to develop strong biological and analytical skills, from mammalian cell culture, flow cytometry, biochemical assays, to molecular biology. Responsibilities:
Conduct research related to cell surface glycoproteomic and glycomic method development, including the implementation of automation for sample processing.
Design and execute experiments related to discovery and validation of cell-type specific targets.
Independently drive research projects and participate in collaborative projects between our laboratory and other academic and industrial partners.
Act as a leader from the bench, driving research programs, strategies, and ideas to completion.
Attend scientific conferences and present results as talks and posters.
Summarize relevant research findings in publications.
Ph.D. in a relevant area of cell biology, biochemistry, physiology, analytical chemistry.
Strongly self-motivated, independent, and ambitious scientist with critical thinking ability.
Very strong organizational and communication skills, creativity in methodological development, and understanding of basic experimental design and statistical analyses.
2-3 years' experience in LC-MS based mass spectrometry
Experience in glycobiology or glycomics
Experience in cell surface or membrane proteomics.
Experience in targeted peptide quantitation, analysis in Skyline.
Experience in mammalian cell culture, immunocytochemistry, flow cytometry, molecular biology
A vital enterprise in the nation’s heartland, the University of Nebraska Medical Center has its eye on improving the future of health care in Nebraska and beyond. As Nebraska’s only public academic health sciences center, UNMC is committed to the education of a 21st century health care work force, to finding cures and treatments for devastating diseases, to providing the best care for patients, and to serving our state and its communities through award-winning outreach. UNMC also is committed to embracing the richness of diversity, and is a major economic engine for the state of Nebraska.Led by Chancellor Jeffrey P. Gold, M.D., UNMC has six colleges and two institutes, serving about 3,700 students in more than two dozen programs. Our primary care program was recently ranked fourth in the nation by U.S. News & World Report, and our physician assistant program was ranked ninth. The university’s physical therapy, pharmacy and public health programs also are ranked among the top in the country. ... Major Units: College of Medicine, College of Nursing, College of Pharmacy, College of Dentistry, College of Public Health, Graduate College, College of Allied Health Professions, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, Munroe-Meyer Institute, Stanley M. Truhlsen Eye Institute.