A postdoctoral position is immediately available in the laboratory of Professor Simon Hogan, Ph.D. within the University of Michigan Mary H. Weiser Food Allergy Center (MHWFAC) and Department of Pathology for candidates with a Ph.D. in computational biology and/or bioinformatics and biostatistics. Broadly, our research aims to understand the role of hematopoietic and non-hematopoietic cell transcriptional and epigenetic mechanisms in regulation of food allergy and anaphylaxis. We are part of the Mary H Weiser Food Allergy Center, a world-leading and multi-disciplinary group committed to advancing our understanding of the immunopathophysiology of food allergy, and developing methods for early detection, diagnosis, and treatment of food allergy.
The successful candidate will have a strong background in computational biology, bioinformatics or biostatistics and expertise in programming and high-throughput analysis of genomic and biological data. The position will involve utilizing computational and bioinformatics approaches to integrate large-scale ChIP-seq, RNA-seq, ATAC-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including scRNA-seq and scATAC-seq data sets derived from human and mouse model systems to identify hematopoietic and non-hematopoietic cell transcriptional and epigenetic events in food allergy and anaphylaxis outcomes. A background in immunology and demonstrated ability to develop novel algorithms and software for the integrative analyses of various experimental genome-wide datasets and large-scale biological databases, and development of novel statistical methods would be advantageous but not a requirement.
Computational analysis and integration of large genomic, transcriptomic and epigenetic datasets.
Access public genetic, epigenetic and transcriptomic large datasets and integrate and analyze these datasets with pre-existing laboratory generated datasets.
Build data analysis pipelines for scRNA-seq and ATAC-seq.
Manage large dataset storage in databases, lab wiki and lab UCSC browser.
Learn research methods that directly relate to the scientific projects with limited direction and supervision.
Present results to laboratory members at weekly lab meetings; present results and data within MHWFAC and Department of Pathology.
Lead collaborative Bioinformatic projects between Hogan lab and other labs in MHWFAC and Department of Pathology.
Working closely with faculty, post-doctoral fellows, and students to integrate bioinformatics outcomes into ongoing research projects.
Attend departmental and Institutional meetings and national and international meetings, as appropriate.
Opportunity for independence and collaborative interactions within the Mary H Weiser Food Allergy Center and Department of Pathology at UM will be provided.
Must possess a Ph.D.
Excellent bioinformatic and programming skills (e.g. Perl, Python, C/C++, Java, R or Web applications).
Strong command of Linux/UNIX operating system.
Strong knowledge and skills in bioinformatics, statistics and next-generation sequencing data analysis.
Ability to use current bioinformatics tools and have an in-depth knowledge of advanced sequencing and array-based technologies.
Experience with Illumina NGS data analysis.
Strong scientific writing and presentation skills, including grant proposals, manuscript preparation, and formal seminars.
Work effectively within an interdisciplinary research team.
A background in immunology
Ability to develop novel algorithms and software for the integrative analyses of various experimental genome-wide datasets and large-scale biological databases.
Ability to development novel statistical methods.
Effective communication and interpersonal skills; strong analytical and problem-solving skills.
Possess strong attention to detail and time management skills.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 172203
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