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Post Doc Instructions:
Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Cardiology. This position is for the Medical School Campus.
Opportunity in Lysosomal biology and Alzheimer’s disease pathogenesis
The Diwan and Lee Labs are seeking an insightful and ambitious postdoctoral researcher to work on the role of lysosomes in microglial and monocytes in Alzheimer’s disease (AD). Our work has been on the forefront of lysosome biology in AD. A new focus of our lab is to study the role of lysosomes in amyloid phagocytosis by microglia and peripheral monocytes recruited to the amyloid plaques. Our studies utilize a variety of genetically targeted mice to experimentally perturb lysosome biology, individually in microglia and monocytes, to determine its affect on AD pathogenesis. We are looking for a scientist looking to join our quest.
Recognizing that science is a journey along planned and unplanned discoveries, our position for a postdoctoral researcher will create opportunities to work with state-of-the art flow cytometry, single cell sequencing and novel ultrasound based techniques for blood brain barrier disruption in animal models of AD as well as potential to develop independent projects. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.
PRIMARY DUTIES AND RESPONSIBILITIES:
Trains under the supervision of a faculty mentor including (but not limited to):
Manages their own project, which should lead to a first author publication.
Develops expertise in flow cytometry, state of the art microscopy and amyloid plaque characterization.
Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
Presents scientific work both inside and outside the University with excellent oral communication skills.
Assists with grant preparation and reporting.
Prepares and submits papers on research with excellent writing skills.
Designs research experiments.
Evaluates research findings and reports results.
Conscientious discharge of his/her research responsibilities.
Maintain conformity with ethical standards in research.
Maintain compliance with good laboratory practice including the maintenance of adequate research records.
Engage in open and timely discussion with his/her mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
Collegial conduct towards co-trainees, staff members and members of the research group.
Adherence to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
The ideal candidate would be an MD or PhD with strong skills in molecular and cell biology.
Experience with animal models (particularly rodent models) as well as cell culture preferred.
Additional skills in proteomics as well as genomics and a grasp of literature review are desirable.
Applicant Special Instructions:
Applicants should send a cover letter including a description of career goals, curriculum vitae, and the names and contact information for 3 references to Drs. Abhinav Diwan (email@example.com) and Jin-Moo Lee (firstname.lastname@example.org).
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.