Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
This position is full-time and works approximately 40 hours per week.
Department Name/Job Location:
This position is in the Department of Cell Biology and Physiology. This position is for the Medical School Campus.
One postdoctoral associate position is available immediately in the laboratory of Dr. Ben Major in the Department of Cell Biology and Physiology at Washington University in St. Louis. The Major lab leverages protein mass spectrometry and functional genomic screens to interrogate signal transduction in various cancers and model systems. Our goal is to better understand altered signaling in cancer to improve the outcome of cancer patients. We have specific interests in and postdoctoral positions open for the following: 1) KEAP1/NRF2 oxidative stress response pathway in lung cancer, head and neck cancer and esophageal cancer, 2) WNT signaling pathway in pancreatic cancer and in lymphoma, and 3) understudied kinases altered in human disease. Our research spans cultured cell lines, 3D organoid systems, mouse models, and patient samples. Our newly funded kinome-centric work aims to physically and functionally characterize 140 understudied kinases. This effort is empowered with our kinome-centric proteomic technologies that reveal kinase inhibitor targets (polypharmacology), differential kinase PTMs and kinase protein stability in cancer/disease. Beyond the bench, opportunities also exist in bioinformatics and computational proteomics. For this and all proteomic work, we operate a new Eclipse-ETD Orbitrap mass spectrometer. Postdoctoral candidates would thus be well resourced and be given unique latitude in developing a research program. Washington University, the Siteman Comprehensive Cancer Center and the Department of Cell Biology and Physiology provides an exceptionally supportive, collaborative, and well-rounded training environment for postdocs.
Prior experience, achievements and letters of recommendation that clearly articulate scientific devotion, drive and curiosity will benefit the applicant.
Applicants must possess a PhD or MD/PhD in a biological science, first author publications, and have experience with signal transduction, cancer cell biology, mouse models of cancer and cell/molecular biology techniques.
A record of accomplishment of leading projects to completion and publication in peer-reviewed journals is required.
Solid coding skills and experience in algorithm development.
Proficiency in R statistical language, Python, and C/C++.
Prior experience with proteomics and mass spectrometry data analysis.
Prior experience in LC/MS operation and maintenance.
General cancer cell signaling and biology. RNAseq/ChIPseq experiments and informatics. Protein-protein interactions and expertise with protein biochemistry. Kinases. Functional genomics and Crispr-A and Crispr-I functional screening.
Small molecule screening, hit validation, target identification, in vivo testing.
Mouse genetic models and cancer-centric phenotyping.
Postdoctoral salary and compensation will meet or exceed NIH guidelines.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Applicant Special Instructions:
Email curriculum vitae, summary of past research experience and accomplishments, and contact information for three references to Dr. M. Ben Major, PhD., Professor of Cell Biology & Physiology, Washington University School of Medicine at email@example.com.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.