A successful candidate will have the opportunity to work closely with Drs., Xiaolin Nan, Shandee Dixon, Joshua Saldivar and other CEDAR researchers to develop key questions related to:
Development of llama derived single domain antibodies with applications to Ras biology & therapeutics in the context of early cancer OR
Early cancer biology with a focus on epigenetic mechanisms of tumorigenesis
We are hiring 1-2 highly motivated Postdoctoral Fellow In the area of cancer early detection and signaling including:
To develop nanobody based cancer early detection and therapy, or to address fundamental questions in the onset of mutant KRas-driven cancers . Current projects are developing and optimizing nanobodies for isoform- and mutation-specific KRas nanobodies. The candidate will work with teams to perform one or more of these tasks: a) establish biological assays for detecting specific KRas forms in cell models, tissues, or liquid biopsies representing early stages of cancer; b) use these novel reagents to address important biological questions with regard to the onset of mutant KRas-driven cancers; and c) evaluate the potential for using the nanobodies and their derivatives for therapeutic targeting of mutant KRas in early stage cancer. Candidate should have prior experience in molecular and cell biology, preferably in cancer biology, signal transduction, or Ras biology. Knowledge of protein chemistry, antibody development, or quantitative imaging is a plus
To investigate fundamental biological processes of cancer initiation. Current interests include deciphering the role of the DNA replication stress response in epigenetic reprogramming and plasticity of pre-malignant cells . We are focused on the ATR-Chk1 signaling pathway and how it rewires the epigenome to promote oncogenesis. This work builds on our recent breakthroughs linking the replication stress response to transcription programs (Saldivar et al., 2017 and 2018, Hamperl et al., 2017)
Other responsibilities include:
Performs experiments utilizing appropriate research techniques with proficiency
Use expert training received in PhD to evaluate results, and determine the next steps to complete project and present data
Think independently and problem solve
Stay on top of the literature and build skills to maximize the projects\u2019 potential
Prepare manuscripts and present research findings as abstracts or oral presentations (travel may be required)
1. Saldivar JC , Cortez D, Cimprich KA. The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Rev. Mol. Cell Biol . 2017; 18(10):622-36.
2. Saldivar JC , Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. An intrinsic S/G2 checkpoint enforced by ATR. Science . 2018; 361(6404):806-810.
3. Hamperl S, Bocek MJ, Saldivar JC , Swigut T, Cimprich KA. Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses. Cell . 2017; 170(4):774-86.
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