The Postdoctoral Scholar will have the opportunity to work with researchers in the CEDAR program, led by Dr. Sadik Esener, and researchers in the Precision Oncology Program, led by Dr. Gordon Mills. CEDAR is focused on detecting and treating lethal cancers at the earliest stage and the Precision Oncology Program is focused on obtaining a deep understanding of patient tumors to identify effective therapy for cancer patients. The Postdoctoral Scholar will work closely with Prof. Gordon Mills, Dr. Hisham Mohammed, and other CEDAR researchers to develop key questions on cancer initiation or develop novel single-cell and proteomics tools relevant to early detection and precision oncology.
Responsibilities and research themes include:
Develop existing or novel technologies with the aim of accurately monitoring biological processes at a single-cell proteomic, transcriptomic, and epigenetic level. The team has previously developed proteomics (RIME, RPPA), single-cell and multi-omic technologies (Mohammed et al, Argelaut et al). Of particular interest is integrating tumor spatial information with single-cell transcriptomics, epigenetics (methylation, chromatin accessibility) and proteomics. This position will leverage unique partnerships with industry innovators.
Investigate fundamental biological processes of cancer initiation and progression. Current interests include deciphering the role of hormone receptors (Mohammed et al, Nature 2018) and deep spatially oriented proteomic analysis of patient tumors to determine therapeutic opportunities. CEDAR researchers have unique access to longitudinal clinical samples and trials to test emerging hypotheses.
Computational biologists with an interest in driving single-cell and multi-omic projects in clinical settings are also encouraged to apply. The position may also involve developing new computational methods and deep learning tools to complement novel technologies developed in the lab.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm