This Research Specialist A position will work on developing and testing nanotechnologies for the treatment of acute critical illnesses, such as ARDS (acute inflammation of the lungs), sepsis, stroke, and others. Our lab packages drugs and gene therapy vectors into nano-scale carriers (~100 nanometers in diameter), and targets them to the organ and cell types of interest using affinity moieties (e.g., antibodies), cell-hitchhiking, and medical devices. We test these in mouse models of acute critical illness, as well as large animal models, and in ex vivo human organs that were deemed unsuitable for organ transplant. We often partner with existing companies and spin out our own start-ups, giving the opportunity to gain experience interacting with industry.
The applicant will perform a broad range of experiments in mouse work, molecular and cell biology, and pharmacology. The methods will include: mouse models of disease followed by organ harvest within 24 hours; histology of mouse organs; flow cytometry of dissociated mouse organs; pharmacological biodistribution experiments (injecting mice with drugs and harvesting organs to determine drug distribution); production of nanoscale drug carriers according to protocols we already have well worked out.
The Principal Investigator will design experiments, but the applicant will be expected to troubleshoot these procedures as needed. The applicant will also keep accurate notebooks, perform data analysis, and assist in publication preparation. Additional duties will include assisting in experimental design, and participating in general laboratory activities such as lab meetings, ordering, and maintenance.
We are looking for applicants who can commit to at least two years in the lab.
Internal Number: 45641
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