The candidate will work in the Upenn High-Throughput Screening Core (HTSC) in the Perelman School of Medicine (PSOM). The primary mission of the core is to provide the PSOM community with high-throughput screening capabilities to identify genes or organic small molecule modulators of signaling pathways, cellular phenotypes, and protein function in models of human disease. He/she will work under the supervision of the Core Directors to optimize and validate cell and biochemical assays in high-density formats (i.e. 384 well microtiter plates). Specific responsibilities will include moderately complex procedures/techniques in eukaryotic/mammalian cell biology, and high-throughput genetic/chemical screening. He/she will operate and maintain automated laboratory robotic workstations related to high-throughput screening; prepare and manage libraries of siRNA, shRNA, cDNA, and small molecule libraries for high-throughput screening; and analyze and prepare reports of large data sets. The candidate will also work with the Directors to strategically develop new screening assays, screening platforms, libraries, or data analysis pipelines. Additional responsibilities will include maintaining articulate documentation of daily tasks and maintenance of the laboratory’s databases/logs and inventory (i.e. supplies, reagents, and equipment).
Internal Number: 45301
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