Under the supervision of the PIthe Researcher, the Research Assistant position investigates and validates heatshock factor HSF1-BDNF axis in CNS in response to acute and chronic stressconditions in the laboratory in the Department of Pharmacology at theUniversity of Tennessee Health Science Center. This project utilizesAlzheimer disease mouse models with fear conditioning and kainic acid(KA)-induced seizure models as well as environment-enriched training (EET); focuson HSF1-mediated BNDF transcriptional regulation and HSF-1-regulated synaptictrancriptome (ChiPseq).
Conducts research in the study of heat shock factor HSF1 regulation of neuroprotection from gene to behavior. The study focuses on HSF1 regulation of promoter-specific transcription of BDNF.
Conducts tissue collection, sample processing (CHIP), qPCR, western blotting, immunohistochemistry, and CHIP seq under PI's supervision.
Generates, analyzes, and present data.
Assists other personnel, managing animal colonies, etc.
Performs other duties as assigned.
Internal Number: 173793
The mission of the University of Tennessee Health Science Center is to bring the benefits of the health sciences to the achievement and maintenance of human health, with a focus on the citizens of Tennessee and the region, by pursuing an integrated program of education, research, clinical care, and public service.