A postdoctoral fellow position is available in the laboratory of Dr. Chao-Yie Yang in the Department of Pharmaceutical Sciences of the University of Tennessee Health Science Center to contribute to our NIH-funded study on development of inhibitors to treat graft versus host disease for patients receiving hematopoietic cell transplantation. Highly motivated applicants with a strong background in synthetic chemistry and a record of productivity are encouraged to apply. Previous experiences in medicinal chemistry and structure-activity relationship studies will be a plus but not required. This is a translational medicine project that we collaborate with a leading physician scientist in the field at Indiana University. The candidate will be trained to learn inhibitor optimization both in potency and pharmacokinetic properties where data will be collected at University of Michigan. These compounds will be evaluated in animal models. Related information of the project can be found in JCI Insight, 2018, 3, e299208 and WO/2017/083242A1. The UT Department of Pharmaceutical Sciences has a strong tradition in medicinal chemistry research program including a rich and collaborative research and training environment and is housed with state-of-the-art facilities.
Dr. Yang's group integrates computer-aided drug design, experimental biophysical techniques and medicinal chemistry synthesis to develop compounds to treat human diseases. The Yang group is interested in developing inhibitors for novel targets relevant to cancers and immune-mediated diseases. The lab is in the College of Pharmacy at the University of Tennessee Health Science Center Campus in Memphis, Tennessee within a vibrant academic biomedical community that includes Le Bonheur Children's Medical Center, St. Jude Children's Research Hospital, and the University of Memphis. Excellent facilities and career development opportunities exist for post-doctoral fellows in the department and across campus.
Internal Number: 174086
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