Research - Laboratory/Non-Laboratory, Staff/Administrative
As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world. UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a "Great College to Work For" for four consecutive years.The Gerner Lab in the Department of Immunology at the UW School of Medicine has an outstanding opportunity for a Research Scientist 3.Research in the Gerner lab uses advanced microscopy technologies, such as multi-parameter confocal imaging and intravital 2-photon microscopy to study the development of immune responses to vaccination, infection, or during cancer. The Research Scientist 3 (RS3) will develop novel methods for in situ analysis of gene expression, in vivo cell photoconversion, or multiparameter image analysis, which will collectively allow a better understanding of how cellular positioning in tissues influences gene expression and cellular function. These new tools and findings will promote a better understanding of immune response generation in vivo, as well as advance biomedical technology develepment.Responsibilities:Technology Development and Experimentation: (70%)Independently develop new methods for in situ analysis of gene expression, in vivo photoconversion, or multiparameter image analysis.Utilize these and other existing methods to study how cellular positioning in tissues influences gene expression and cell function. Methods and software used include MATLAB, R, LASX, Imaris, and Histocytometry. The lab uses multiplex confocal imaging and Histocytometry (10.1016/j.immuni.2012.07.011, 10.1016/j.immuni.2014.12.024, 10.1073/pnas.1708981114), as well as in vivo photoconversion (10.1126/science.aao4277) to identify localized cell events and study cellular gene expression based on tissue positioning.In collaboration with the research team, the incumbent will try to establish published, as well as develop novel technologies to analyze the gene expression in cells while retaining information on their position within intact tissues. These data will allow the team to link how cellular positioning in tissues and exposure to localized microenvironment influences gene expression.Data Analysis/Reporting, Data Presentation, and Scientific Manuscript Writing: (30%)Incumbent will regularly present their findings in lab meetings and departmental seminars and at professional conferences.Incumbent will be expected to published findings in peer-reviewed journals.The RS3 will work highly independently with regular oversight from the PI. The RS3 may also help train and monitor the work of junior staff using the developed tools and will interact in a collaborative manner with other teams to accomplish overarching goals. The RS3 will provide ideas to the rest of the group to improve overall efficiency.Minimum Requirements:Master's degree in Bioinformatics, Biotechnology, Immunology, or related field.At least three years of relevant experience, including experience with microscopy, bioinformatics, and analysis of gene expression.Desired:Doctoral degree in Bioinformatics, Biotechnology, Immunology, or related field.Programming skills, R, cell culture, Immunological assays.Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.Application Process:The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
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