Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Willing and able to handle and train animals.
Experience in the following is highly desired: image and signal processing, hardware and software development, electronics, optics, diffuse optics, experimental design, neuroimaging, multivariate analysis, and programming (MATLAB, C, C++, etc.).
Basic understanding of neuroscience, injections, and tissue processing for downstream cellular and molecular analyses.
Works well in a team.
Ability to learn new things quickly, work independently and communicate clearly.
A postdoctoral research position is available in the Optical Radiology Laboratory at Washington University School of Medicine in St. Louis working with Dr. Adam Bauer. The successful candidate will take the lead on an NIH-funded project developing new optical imaging technology for examining brain repair after stroke in mice. This position offers the opportunity to work with a multi-disciplinary research team including faculty from the Departments of Radiology, Neuroscience, Biomedical Engineering, Radiation Oncology, Anesthesiology, Biology, Genetics, Electrical & Systems Engineering, and Physics. A candidate with a collaborative spirit who is eager to take advantage of available resources here will thrive.
The Bauer Lab develops optical imaging techniques for mapping functional brain organization in mice for translational neuroscience applications. We are particularly interested in understanding the functional role of spontaneous brain activity, how functional network connectivity in the mouse brain is affected after injury, and if stroke recovery can be improved using the brain’s endogenous physiology. To help us answer these questions, we use the latest advances in transgenic mouse lines, viral vector targeting and optogenetics. Funding sources include NIH, AHA, and the McDonnell Center. Techniques being developed and applied include wide-field optical mapping of hemoglobin, genetically encoded calcium indicators, and laser speckle contrast; optogenetic mapping of axonal projection connectivity; and mapping motor movements using optogenetics and machine vision analysis. Neuroscience topics include neurovascular coupling, functional connectivity, cortical plasticity with applications to stroke, Alzheimer’s disease, and development. We have the advantages of a large, collaborative center with several core facilities available.
"Sensory Deprivation Following Focal Ischemia Accelerates Remapping and Behavioral Recovery through Arc-Dependent Synaptic Plasticity", Science Translational Medicine, 10(426), 2018
"Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct from Resting State Functional Connectivity in the Mouse", Cerebral Cortex, 28(1), 2018
“Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke”, NeuroImage: Clinical, 17(1), 2018
“Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components”, Neurobiology of Disease, 112(1), 2018
“Distinct temporal and laminar relationships in spontaneous infra-slow brain activity”, Neuron, 98(2), 2018
“Mapping structure-function relationships in the brain”, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Accepted October 2018
"Functional Connectivity Structure of Cortical Calcium Dynamics in Anesthetized and Awake Mice", PLoS One, 12(10): e0185759, 2017
PhD in physics, biomedical engineering, electrical engineering, computer science, applied mathematics, imaging science, neuroscience, or a related field and a strong background in research and method development.
This position is full-time and works approximately 40 hours per week.
Department Name/Job Location:
This position is in the Department of Radiology. This position is for the Medical School Campus.
Base pay commensurate with experience.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.