Berkeley Lab's Molecular Biophysics & Integrated Bioimaging Division has an opening for a Biochemist Postdoctoral Scholar. Under the general supervision of SIBYLS beamline scientists under the inter-disciplinary SIBYLS beamline (ALS 12.3.1), the Biochemist Postdoctoral Scholar will develop and apply biophysical and biochemical techniques to address questions relevant to understanding structural cell biology for multi-component biological macromolecules.
Purification and structural characterization of microbial metalloproteins as part of a large multi-institution program to characterize and potentially utilize their unique catalytic capabilities in microbial metabolism. Many of the proteins of interest come from organisms that have established niches in challenging environments. You will purify these proteins from cells that have been grown in large quantities by collaborators. Purification will often be done under anaerobic conditions. Purification will be assayed using gels and size exclusion related methods. These proteins will be further structurally characterized using small angle X-ray scattering (SAXS), X-ray crystallography and cryo electron microscopy. You will be required to troubleshoot purification and evolve their structural characterization skills with staff at the Advanced Light Source synchrotron.
What You Will Do:
Participate with other members of the SIBYLS team in design and implementation of instrumentation and methodology that will maximize efficient and productive data analysis from both SAXS and crystallography. This will include improving automation. Duties as part of the team will include beamline maintenance and user support.
Publish scientific papers in peer-reviewed journals and present findings at seminars and conferences.
Participate in development of grant proposals for new research directions and preparation of competing renewals of current research grants.
Maintain an accurate and detailed online laboratory notebook of all experiments performed and provide sufficient details to ensure methods and results can be duplicated by others.
Collaborate with program projects that utilize the beamline for research and develop new collaborations as appropriate to further the scientific goals of the SIBYLS programs.
Cooperate with other members of the SIBYLS beamline and the Advanced Light Source division.
Additional Responsibilities as needed:
Participate in professional scientific activities, e.g., reviews of papers, research proposals, etc.
Support and contribute to the development of research project ideas and proposals.
Participate in relevant professional societies with relevance to the program and group activities.
What Is Required:
PhD in biology, chemistry, physics or related degree.
Competent computer skills.
Experience in purification of proteins.
Capacity to work with a large team of investigators.
Ability to take detailed notes so that work could be replicated.
Excellent written and verbal communication skills.
Ability to work in a diverse environment.
Additional Desired Qualifications:
Experience in structural biology.
The posting shall remain open until the position is filled.
This is a full time, 3 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 2 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
Full-time, M-F, exempt (monthly paid) from overtime pay.
This position is represented by a union for collective bargaining purposes.
Salary will be predetermined based on postdoctoral step rates.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at: Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with thePay Transparency Nondiscrimination Provisionunder 41 CFR 60-1.4. Clickhere to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 86373
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.