A Postdoctoral Fellow position with a bioinformatics/computational, experimental, or dual focus is available immediately in the laboratory of Dr. Brian J. O\u2019Roak, Department of Molecular and Medical Genetics at Oregon Health & Science University (OHSU) for highly motivated individuals. Highlights of Dr. O\u2019Roak\u2019s past research successes include: pioneering trio-based exome sequencing in simplex autism and developing new technologies for rapid and economical targeted resequencing.
We are building on this experience by forming a strong and diverse research group focused on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders. This work has the potential to dramatically improve the lives of individuals affected with these currently untreatable disorders through early intervention and biologically based personal therapies.
Areas of interest include: genomics, single-cell genomics, modeling of neurodevelopmental disorders in stem cell (iPSC) and animal systems, massively parallel functional assays, and bioinformatics.
In particular, there is an immediate need for a fellow with next-generation sequence analysis experience to lead a project exploring the role of germline mutations and somatic mosaicism in autism and other neurodevelopmental disorders (e.g. neural tube detects), for which long-term funding currently exists. This would build on our work recently published in the AJHG (see Krupp et al. 2017).
Candidates with Ph.D., M.D., or equivalent degrees and intensive training in the areas of genetics/genomics, molecular biology or biochemistry, neuroscience, computer science, bioinformatics are encouraged to apply.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm